Structure of PDB 1tcv Chain C

Receptor sequence
>1tcvC (length=280) Species: 6183 (Schistosoma mansoni) [Search protein sequence]
SVTANIENVKKVAHHIQKLTSIVPEIGIICGSGLGKLADGVKDKITIPYT
KIPNFPQTHSGNLIFGTLSGRKVVVMQGRFHMYEGYSNDTVALPIRVMKL
LGVKILMVSNAAGGLNRSLKLGDFVILKDHIYLPGLGLNNILVGPNQEAF
GTRFPALSNAYDRDLRKLAVQVAEENGFGNLVHQGVYVMNGGPCYETPAE
CTMLLNMGCDVVGMSTIPEVVIARHCGIQVFAVSLVTNISVLDVESDLKP
NHEEVLATGAQRAELMQSWFEKIIEKLPKD
3D structure
PDB1tcv Structures for the Potential Drug Target Purine Nucleoside Phosphorylase from Schistosoma mansoni Causal Agent of Schistosomiasis.
ChainC
Resolution1.75 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S35 H66 H88 Y90 E91 A118 M221 S222 N245 S247 H259
Catalytic site (residue number reindexed from 1) S32 H59 H81 Y83 E84 A111 M214 S215 N238 S240 H252
Enzyme Commision number 2.4.2.1: purine-nucleoside phosphorylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ACT C A119 G120 Y202 E203 V219 N245 A112 G113 Y195 E196 V212 N238
BS02 NDS C H88 Y90 A118 Y202 M221 S222 H81 Y83 A111 Y195 M214 S215
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004731 purine-nucleoside phosphorylase activity
GO:0016757 glycosyltransferase activity
GO:0047975 guanosine phosphorylase activity
Biological Process
GO:0006139 nucleobase-containing compound metabolic process
GO:0009116 nucleoside metabolic process
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Cellular Component
External links
PDB RCSB:1tcv, PDBe:1tcv, PDBj:1tcv
PDBsum1tcv
PubMed16182308
UniProtQ9BMI9

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