Structure of PDB 1t2v Chain C

Receptor sequence
>1t2vC (length=202) Species: 9606 (Homo sapiens) [Search protein sequence]
RMSMVVSGLTPEEFMLVYKFARKHHITLTNLITEETTHVVMKTDAEFVCE
RTLKYFLGIAGGKWVVSYFWVTQSIKERKMLNEHDFEVRGDVVNGRNHQG
PKRARESQDRKIFRGLEICCYGPFTNMPTDQLEWMVQLCGASVVKELSSF
THPIVVVQPDAWTFHAIGQMCEAPVVTREWVLDSVALYQCQELDTYLIPQ
IP
3D structure
PDB1t2v Structural basis of phosphopeptide recognition by the BRCT domain of BRCA1
ChainC
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C C1768 G1770 P1771 F1772 N1774 P1776 T1777 K1793 E1794 C120 G122 P123 F124 N126 P128 T129 K145 E146
BS02 peptide C S1655 G1656 T1658 P1659 E1698 R1699 T1700 K1702 V1741 N1774 M1775 E1836 S7 G8 T10 P11 E50 R51 T52 K54 V93 N126 M127 E179
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
Biological Process
GO:0006281 DNA repair
GO:0006974 DNA damage response
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1t2v, PDBe:1t2v, PDBj:1t2v
PDBsum1t2v
PubMed15133503
UniProtP38398|BRCA1_HUMAN Breast cancer type 1 susceptibility protein (Gene Name=BRCA1)

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