Structure of PDB 1sq5 Chain C

Receptor sequence
>1sq5C (length=298) Species: 562 (Escherichia coli) [Search protein sequence]
MTPYLQFDRNQWAALRMTLSEDEIARLKGINEDLSLEEVAEIYLPLSRLL
NFYISSNLRRQAVLEQFLGTNRPYIISIAGSVAVGKSTTARVLQALLSRW
PERVELITTDGFLHPNQVLKERGLMKKKGFPESYDMHRLVKFVSDLKSGV
PNVTAPVYSHLIYDVIPDGDKTVVPDILILEGLNVLQSGMDYPHDPHHVF
VSDFVDFSIYVDAPEDLLQTWYINRFLKFREGAFTDPDSYFHNYAKLTKE
EAIKTAMTLWKEINWLNLKQNILPTRERASLILTKSANHAVEEVRLRK
3D structure
PDB1sq5 The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites.
ChainC
Resolution2.2 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.33: pantothenate kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PAU C D3127 K3145 G3146 H3177 Y3240 I3281 N3282 D110 K128 G129 H160 Y222 I263 N264
BS02 ADP C A3098 V3099 G3100 K3101 S3102 T3103 R3243 H3307 A83 V84 G85 K86 S87 T88 R225 H289
Gene Ontology
Molecular Function
GO:0004594 pantothenate kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0042803 protein homodimerization activity
GO:0050165 pantetheine kinase activity
Biological Process
GO:0015937 coenzyme A biosynthetic process
GO:0016310 phosphorylation
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1sq5, PDBe:1sq5, PDBj:1sq5
PDBsum1sq5
PubMed15136582
UniProtP0A6I3|COAA_ECOLI Pantothenate kinase (Gene Name=coaA)

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