Structure of PDB 1so2 Chain C

Receptor sequence
>1so2C (length=372) Species: 9606 (Homo sapiens) [Search protein sequence]
LDLILVEEYDSLIEKMSNWNFPIFELVEKMGEKSGRILSQVMYTLFQDTG
LLEIFKIPTQQFMNYFRALENGYRDIPYHNRIHATDVLHAVWYLTTRPVP
GLQQIHNGCDSDGRINHGRIAYISSKSCSNPDESYGCLSSNIPALELMAL
YVAAAMHDYDHPGRTNAFLVATNAPQAVLYNDRSVLENHHAASAWNLYLS
RPEYNFLLHLDHVEFKRFRFLVIEAILATDLKKHFDFLAEFNAKANDVNS
NGIEWSNENDRLLVCQVCIKLADINGPAKVRDLHLKWTEGIVNEFYEQGD
EEANLGLPISPFMDRSSPQLAKLQESFITHIVGPLCNSYDAAGLLPGQWL
ESRRRIFCQLMHHLTENHKIWK
3D structure
PDB1so2 Crystal Structure of Human Phosphodiesterase 3B: Atomic Basis for Substrate and Inhibitor Specificity
ChainC
Resolution2.4 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.1.4.17: 3',5'-cyclic-nucleotide phosphodiesterase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C H741 H821 D822 D937 H83 H157 D158 D273
BS02 666 C L895 I938 G940 P941 H948 T952 F959 L987 Q988 S990 F991 L231 I274 G276 P277 H284 T288 F295 L323 Q324 S326 F327 MOAD: ic50=0.27nM
Gene Ontology
Molecular Function
GO:0004114 3',5'-cyclic-nucleotide phosphodiesterase activity
GO:0008081 phosphoric diester hydrolase activity
Biological Process
GO:0007165 signal transduction

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Molecular Function
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Biological Process
External links
PDB RCSB:1so2, PDBe:1so2, PDBj:1so2
PDBsum1so2
PubMed15147193
UniProtQ13370|PDE3B_HUMAN cGMP-inhibited 3',5'-cyclic phosphodiesterase 3B (Gene Name=PDE3B)

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