Structure of PDB 1sa0 Chain C

Receptor sequence
>1sa0C (length=421) Species: 9913 (Bos taurus) [Search protein sequence]
RECISIHVGQAGVQIGNACWELYCLEHGIQPDGQMDSFNTFFSETGAGKH
VPRAVFVDLEPTVIDEVRTGTYRQLFHPEQLITGKEDAANNYARGHYTIG
KEIIDLVLDRIRKLADQCTGLQGFSVFHSFGGGTGSGFTSLLMERLSVDY
GKKSKLEFSIYPAPQVSTAVVEPYNSILTTHTTLEHSDCAFMVDNEAIYD
ICRRNLDIERPTYTNLNRLIGQIVSSITASLRFDGALNVDLTEFQTNLVP
YPRIHFPLATYAPVISAEQLSVAEITNACFEPANQMVKCDPRHGKYMACC
LLYRGDVVPKDVNAAIATIKTKRTIQFVDWCPTGFKVGINYEPPTVVPGG
DLAKVQRAVCMLSNTTAIAEAWARLDHKFDLMYAKRAFVHWYVGEGMEEG
EFSEAREDMAALEKDYEEVGV
3D structure
PDB1sa0 Insight into tubulin regulation from a complex with colchicine and a stathmin-like domain.
ChainC
Resolution3.58 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.6.5.-
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C G144 T145 G133 T134
BS02 GTP C G10 Q11 A12 I16 E71 S140 G143 G144 T145 G146 S178 N206 Y224 N228 G9 Q10 A11 I15 E60 S129 G132 G133 T134 G135 S167 N195 Y213 N217
BS03 CN2 C S178 V181 S167 V170
Gene Ontology
Molecular Function
GO:0005200 structural constituent of cytoskeleton
GO:0005525 GTP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0000226 microtubule cytoskeleton organization
GO:0000278 mitotic cell cycle
GO:0007017 microtubule-based process
Cellular Component
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0005874 microtubule

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1sa0, PDBe:1sa0, PDBj:1sa0
PDBsum1sa0
PubMed15014504
UniProtQ2HJ86|TBA1D_BOVIN Tubulin alpha-1D chain (Gene Name=TUBA1D)

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