Structure of PDB 1s4e Chain C

Receptor sequence
>1s4eC (length=337) Species: 2261 (Pyrococcus furiosus) [Search protein sequence]
ITVKSPGRVNLIGEHTDYTYGYVMPMAIDLYTIITAEKKVQLYSEHFNEK
TFTLDNLKEGSWIDYVKGVLWVLIQEGYIGGLKGKITGDLPLGAGLSSSA
SFEVGILEVLNQLYNLNIDPLKKALLAKKAENEFVGVPCGILDQFAVVFG
KKDNVIFLDTQTLQYEYIPFPKDVSVLVFYTGVKRELASSEYAERKRIAE
ESLRILGKESSKEVTEKDLGKLPPLHRKFFSYIVRENARVLEVRDALKED
IEKVGKILTTAHWDLAENYRVSCELDFFVKKAMELAYGARLTGAGFGGSA
IALVDKDKAKTIGDALRELAKFSWKAKYFVVKPSDGV
3D structure
PDB1s4e Substrate specificity and mechanism from the structure of Pyrococcus furiosus galactokinase
ChainC
Resolution2.9 Å
3D
structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Enzyme Commision number 2.7.1.6: galactokinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 GLA C E17 H18 D20 G148 Y200 E14 H15 D17 G140 Y192
BS02 ADP C S49 W69 Y72 I94 L100 G101 A102 S105 S106 S107 S44 W62 Y65 I86 L92 G93 A94 S97 S98 S99
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004335 galactokinase activity
GO:0005524 ATP binding
GO:0005534 galactose binding
GO:0016301 kinase activity
GO:0016773 phosphotransferase activity, alcohol group as acceptor
GO:0046872 metal ion binding
Biological Process
GO:0006012 galactose metabolic process
GO:0016310 phosphorylation
GO:0046835 carbohydrate phosphorylation
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1s4e, PDBe:1s4e, PDBj:1s4e
PDBsum1s4e
PubMed15003454
UniProtQ9HHB6|GAL1_PYRFU Galactokinase (Gene Name=galK)

[Back to BioLiP]