Structure of PDB 1rxt Chain C

Receptor sequence
>1rxtC (length=325) Species: 9606 (Homo sapiens) [Search protein sequence]
DLGDRGVLKELYTLLNENYVEDDDNMFRFDYSPEFLLWALRPPGWLPQWH
CGVRGFISAIPANIHIYDTEKKMVEINFLCVHKKLRSKRVAPVLIREITR
RVHLEGIFQAVYTAGVVLPKPVGTCRYWHRSLNPRKLIEVKFSHLSRNMT
MQRTMKLYRLPETPKTAGLRPMETKDIPVVHQLLTRYLKQFHLTPVMSQE
EVEHWFYPQENIIDTFVVENANGEVTDFLSFYTLPSTIMNTHKSLKAAYS
FYNVHTQTPLLDLMSDALVLAKMKGFDVFNALDLMENKTFLEKLKFGIGD
GNLQYYLYNWKCPSMGAEKVGIVLQ
3D structure
PDB1rxt Crystal structure of human myristoyl-CoA:protein N-myristoyltransferase
ChainC
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N169 F170 L171 T205 Q455
Catalytic site (residue number reindexed from 1) N77 F78 L79 T113 Q325
Enzyme Commision number 2.3.1.-
2.3.1.97: glycylpeptide N-tetradecanoyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CO C L276 F298 F326 Y352 L184 F206 F228 Y252
Gene Ontology
Molecular Function
GO:0004379 glycylpeptide N-tetradecanoyltransferase activity
GO:0005515 protein binding
GO:0016746 acyltransferase activity
GO:0018030 peptidyl-lysine N6-myristoyltransferase activity
GO:0019107 myristoyltransferase activity
Biological Process
GO:0001701 in utero embryonic development
GO:0006499 N-terminal protein myristoylation
GO:0018008 N-terminal peptidyl-glycine N-myristoylation
GO:0022400 regulation of opsin-mediated signaling pathway
GO:0042180 cellular ketone metabolic process
GO:0072657 protein localization to membrane
GO:1903749 positive regulation of establishment of protein localization to mitochondrion
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol
GO:0005886 plasma membrane
GO:0016020 membrane

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Molecular Function
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Cellular Component
External links
PDB RCSB:1rxt, PDBe:1rxt, PDBj:1rxt
PDBsum1rxt
PubMed
UniProtP30419|NMT1_HUMAN Glycylpeptide N-tetradecanoyltransferase 1 (Gene Name=NMT1)

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