Structure of PDB 1q1t Chain C

Receptor sequence

>1q1tC (length=427) Species: 10090 (Mus musculus) [Search protein sequence]

NQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAG
LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFIS
LLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLS
TLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLA
DSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGN
IVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQ
IQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC
GIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGG
LDKIEALQRHENESVYKASLNLIEKYF

3D structure

PDB

1q1t Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha

Chain

Resolution

2.5 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	D280 G281 N283 R315 V321 T322 T328 E354 W357 S360 N361 E396 W399 S406	D211 G212 N214 R246 V252 T253 T259 E285 W288 S291 N292 E327 W330 S337
BS02	peptide	C	S105 R106 E107 P110 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 W273 Y277	S36 R37 E38 P41 W73 N77 S80 G81 T86 Q112 W115 N119 G122 D123 W162 R169 W204 Y208

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1q1t, PDBe:1q1t, PDBj:1q1t
PDBsum	1q1t
PubMed	12852786
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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