Structure of PDB 1q1s Chain C

Receptor sequence

>1q1sC (length=434) Species: 10090 (Mus musculus) [Search protein sequence]

MADIGSNQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPID
NIIRAGLIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGA
IPAFISLLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALL
AVPDLSTLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHN
DPEVLADSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPA
LRAIGNIVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNIT
AGRQDQIQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQI
VYLVHCGIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIM
IEECGGLDKIEALQRHENESVYKASLNLIEKYFS

3D structure

PDB

1q1s Role of flanking sequences and phosphorylation in the recognition of the simian-virus-40 large T-antigen nuclear localization sequences by importin-alpha

Chain

Resolution

2.3 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	peptide	C	V321 T322 T328 W357 S360 N361 E396 N403 S406	V258 T259 T265 W294 S297 N298 E333 N340 S343
BS02	peptide	C	M64 A65 S105 R106 P110 W142 N146 S149 G150 T155 Q181 W184 N188 G191 D192 W231 R238 W273 Y277 L307 P308	M1 A2 S42 R43 P47 W79 N83 S86 G87 T92 Q118 W121 N125 G128 D129 W168 R175 W210 Y214 L244 P245

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:1q1s, PDBe:1q1s, PDBj:1q1s
PDBsum	1q1s
PubMed	12852786
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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