Structure of PDB 1q17 Chain C

Receptor sequence
>1q17C (length=295) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
HGMASMSVSTASTEMSVRKIAAHMKSNPNAKVIFMVGAGISTSCGIPDFR
SPGTGLYHNLARLKLPYPEAVFDVDFFQSDPLPFYTLAKELYPGNFRPSK
FHYLLKLFQDKDVLKRVYTQNIDTLERQAGVKDDLIIEAHGSFAHCHCIG
CGKVYPPQVFKSKLAEHPIKDFVKCDVCGELVKPAIVFFGEDLPDSFSET
WLNDSEWLREKIKHPQQPLVIVVGTSLAVYPFASLPEEIPRKVKRVLCNL
ETVGDFKANKRPTDLIVHQYSDEFAEQLVEELGWQEDFEKILTAQ
3D structure
PDB1q17 Structure of the Yeast Hst2 Protein Deacetylase in Ternary Complex with 2'-O-Acetyl ADP Ribose and Histone Peptide.
ChainC
Resolution2.7 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) P42 D43 F44 R45 N116 D118 H135
Catalytic site (residue number reindexed from 1) P47 D48 F49 R50 N121 D123 H140
Enzyme Commision number 2.3.1.286: protein acetyllysine N-acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C C143 C146 C170 C173 C148 C151 C175 C178
BS02 APR C G32 A33 G34 T37 D43 F44 R45 Y52 Q115 G223 T224 S225 N248 L249 Y269 S270 G37 A38 G39 T42 D48 F49 R50 Y57 Q120 G224 T225 S226 N249 L250 Y270 S271
Gene Ontology
Molecular Function
GO:0017136 NAD-dependent histone deacetylase activity
GO:0051287 NAD binding
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:1q17, PDBe:1q17, PDBj:1q17
PDBsum1q17
PubMed14604530
UniProtP53686|HST2_YEAST NAD-dependent protein deacetylase HST2 (Gene Name=HST2)

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