Structure of PDB 1pyo Chain C

Receptor sequence
>1pyoC (length=161) Species: 9606 (Homo sapiens) [Search protein sequence]
CLQVKPCTPEFYQTHFQLAYRLQSRPRGLALVLSNVHFTGEKELEFRSGG
DVDHSTLVTLFKLLGYDVHVLCDQTAQEMQEKLQNFAQLPAHRVTDSCIV
ALLSHGVEGAIYGVDGKLLQLQEVFQLFDNANCPSLQNKPKMFFIQACRG
DETDRGVDQQD
3D structure
PDB1pyo Crystal structure of caspase-2, apical initiator of the intrinsic apoptotic pathway.
ChainC
Resolution1.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E52 F53 G113 C155
Catalytic site (residue number reindexed from 1) E45 F46 G106 C148
Enzyme Commision number 3.4.22.55: caspase-2.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R54 H112 Q153 C155 R47 H105 Q146 C148
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1pyo, PDBe:1pyo, PDBj:1pyo
PDBsum1pyo
PubMed12920126
UniProtP42575|CASP2_HUMAN Caspase-2 (Gene Name=CASP2)

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