Structure of PDB 1pqu Chain C

Receptor sequence
>1pquC (length=356) Species: 71421 (Haemophilus influenzae Rd KW20) [Search protein sequence]
MKNVGFIGWRGMVGSVLMDRMSQENDFENLNPVFFTTSQLKSAFDIEELK
KLDIIVTCQGGDYTNEVYPKLKATGWDGYWVDAASALRMKDDAIIVLDPV
NQHVISEGLKKGIKTFVGGNCTVSLMLMAIGGLFEKDLVEWISVATYQAA
SGAGAKNMRELLSQMGLLEQAVSSELKDPASSILDIERKVTAKMRADNFP
TDNFGAALGGSLIPWIDKLLPETGQTKEEWKGYAETNKILGLSDNPIPVD
GLCVRIGALRCNSQAFTIKLKKDLPLEEIEQIIASHNEWVKVIPNDKEIT
LRELTPAKVTGTLSVPVGRLRKLAMGPEYLAAFTVGDQLLWGAAEPVRRI
LKQLVA
3D structure
PDB1pqu The role of substrate-binding groups in the mechanism of aspartate-beta-semialdehyde dehydrogenase.
ChainC
Resolution1.92 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) C136 Q163 R270 N277
Catalytic site (residue number reindexed from 1) C121 Q148 R255 N262
Enzyme Commision number 1.2.1.11: aspartate-semialdehyde dehydrogenase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 CYS C C136 Q163 G167 E243 R270 Q353 C121 Q148 G152 E228 R255 Q338
Gene Ontology
Molecular Function
GO:0004073 aspartate-semialdehyde dehydrogenase activity
GO:0016491 oxidoreductase activity
GO:0016620 oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor
GO:0046983 protein dimerization activity
GO:0050661 NADP binding
GO:0051287 NAD binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009085 lysine biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0009088 threonine biosynthetic process
GO:0009089 lysine biosynthetic process via diaminopimelate
GO:0009097 isoleucine biosynthetic process
GO:0019877 diaminopimelate biosynthetic process
GO:0071266 'de novo' L-methionine biosynthetic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1pqu, PDBe:1pqu, PDBj:1pqu
PDBsum1pqu
PubMed15272161
UniProtP44801|DHAS_HAEIN Aspartate-semialdehyde dehydrogenase (Gene Name=asd)

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