Structure of PDB 1pqc Chain C

Receptor sequence
>1pqcC (length=231) Species: 9606 (Homo sapiens) [Search protein sequence]
LTAAQELMIQQLVAAQLQCNKRSFKVTPWPLQSRDARQQRFAHFTELAII
SVQEIVDFAKQVPGFLQLGREDQIALLKASTIEIMLLETARRYNHETECI
TFLKDFTYSKDDFHRAGLQVEFINPIFEFSRAMRRLGLDDAEYALLIAIN
IFSADRPNVQEPGRVEALQQPYVEALLSYTRIKRPQDQLRFPRMLMKLVS
LRTLSSVHSEQVFALRLQDKKLPPLLSEIWD
3D structure
PDB1pqc The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands.
ChainC
Resolution2.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 444 C F271 L274 A275 M312 L313 T316 I353 H435 W457 F44 L47 A48 M85 L86 T89 I126 H208 W230 BindingDB: IC50=9nM,EC50=170nM,Ki=41nM,Kd=103nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006629 lipid metabolic process

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Molecular Function
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Biological Process
External links
PDB RCSB:1pqc, PDBe:1pqc, PDBj:1pqc
PDBsum1pqc
PubMed12819202
UniProtP55055|NR1H2_HUMAN Oxysterols receptor LXR-beta (Gene Name=NR1H2)

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