Structure of PDB 1p19 Chain C

Receptor sequence
>1p19C (length=185) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
PREYEFAEKILFTEEEIRTRIKEVAKRIADDYKGKGLRPYVNPLVLISVL
KGSFMFTADLCRALCDFNVPVRMEFICVSSYGESGQVRMLLDTRHSIEGH
HVLIVEDIVDTALTLNYLYHMYFTRRPASLKTVVLLDKREGRRVPFSADY
VVANIPNAFVIGYGLDYDDTYRELRDIVVLRPEVY
3D structure
PDB1p19 Interactions at the dimer interface influence the relative efficiencies for purine nucleotide synthesis and pyrophosphorolysis in a phosphoribosyltransferase.
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E111 D112 D115 F164 R177
Catalytic site (residue number reindexed from 1) E106 D107 D110 F159 R172
Enzyme Commision number 2.4.2.8: hypoxanthine phosphoribosyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 IMP C D112 I113 T116 F164 V165 L170 D171 D107 I108 T111 F159 V160 L165 D166 MOAD: Kd=76.8uM
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0000287 magnesium ion binding
GO:0004422 hypoxanthine phosphoribosyltransferase activity
GO:0016757 glycosyltransferase activity
GO:0046872 metal ion binding
GO:0052657 guanine phosphoribosyltransferase activity
Biological Process
GO:0006166 purine ribonucleoside salvage
GO:0006178 guanine salvage
GO:0032263 GMP salvage
GO:0032264 IMP salvage
GO:0046100 hypoxanthine metabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Biological Process
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Cellular Component
External links
PDB RCSB:1p19, PDBe:1p19, PDBj:1p19
PDBsum1p19
PubMed14698288
UniProtQ4DRC4

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