Structure of PDB 1ovm Chain C

Receptor sequence
>1ovmC (length=535) Species: 550 (Enterobacter cloacae) [Search protein sequence]
TPYCVADYLLDRLTDCGADHLFGVPGDYNLQFLDHVIDSPDICWVGCANE
LNASYAADGYARCKGFAALLTTFGVGELSAMNGIAGSYAEHVPVLHIVGA
PGTAAQQRGELLHHTLGDGEFRHFYHMSEPITVAQAVLTEQNACYEIDRV
LTTMLRERRPGYLMLPADVAKKAATPPVNALTHKQAHADSACLKAFRDAA
ENKLAMSKRTALLADFLVLRHGLKHALQKWVKEVPMAHATMLMGKGIFDE
RQAGFYGTYSGSASTGAVKEAIEGADTVLCVGTRFTDTLTAGFTHQLTPA
QTIEVQPHAARVGDVWFTGIPMNQAIETLVELCKQHVHAPDGSLTQENFW
RTLQTFIRPGDIILADQGTSAFGAIDLRLPADVNFIVQPLWGSIGYTLAA
AFGAQTACPNRRVIVLTGDGAAQLTIQELGSMLRDKQHPIILVLNNEGYT
VERAIHGAEQRYNDIALWNWTHIPQALSLDPQSECWRVSEAEQLADVLEK
VAHHERLSLIEVMLPKADIPPLLGALTKALEACNN
3D structure
PDB1ovm Crystal structure of thiamindiphosphate-dependent indolepyruvate decarboxylase from Enterobacter cloacae, an enzyme involved in the biosynthesis of the plant hormone indole-3-acetic acid
ChainC
Resolution2.65 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G28 D29 Y30 N31 E52 T74 H115 H116 L118 G119 A169 S264 L291 Q383 G408 I410 D435 N462 G464 V467 E468 I471 K532
Catalytic site (residue number reindexed from 1) G26 D27 Y28 N29 E50 T72 H113 H114 L116 G117 A167 S262 L289 Q367 G392 I394 D419 N446 G448 V451 E452 I455 K516
Enzyme Commision number 4.1.1.74: indolepyruvate decarboxylase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C D435 N462 G464 D419 N446 G448
BS02 TPP C T385 G408 S409 I410 G434 G436 A437 N462 G464 Y465 T466 V467 E468 T369 G392 S393 I394 G418 G420 A421 N446 G448 Y449 T450 V451 E452
BS03 TPP C V26 P27 E52 V77 V24 P25 E50 V75
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003824 catalytic activity
GO:0004737 pyruvate decarboxylase activity
GO:0016831 carboxy-lyase activity
GO:0030976 thiamine pyrophosphate binding
GO:0046872 metal ion binding
GO:0047434 indolepyruvate decarboxylase activity
Biological Process
GO:0000949 aromatic amino acid family catabolic process to alcohol via Ehrlich pathway
GO:0009851 auxin biosynthetic process
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ovm, PDBe:1ovm, PDBj:1ovm
PDBsum1ovm
PubMed12752451
UniProtP23234|DCIP_ENTCL Indole-3-pyruvate decarboxylase (Gene Name=ipdC)

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