Structure of PDB 1oj7 Chain C

Receptor sequence

>1oj7C (length=390) Species: 83333 (Escherichia coli K-12)

KAGLNNFNLHTPTRILFGKGAIAGLREQIPHDARVLITYGGGSVKKTGVL
DQVLDALKGMDVLEFGGIEPNPAYETLMNAVKLVREQKVTFLLAVGGGSV
LDGTKFIAAAANYPENIDPWHILQTGGKEIKSAIPMGCVLTLPATGSESN
AGAVISRKTTGDKQAFHSAHVQPVFAVLDPVYTYTLPPRQVANGVVDAFV
HTVEQYVTKPVDAKIHDRFAEGILLTLIEDGPKALKEPENYDVRANVMWA
ATQALNGLIGAGVPQDWATHMLGHELTAMHGLDHAQTLAIVLPALWNEKR
DTKRAKLLQYAERVWNITEGSDDERIDAAIAATRNFFEQLGVPTHLSDYG
LDGSSIPALLKKLEEHGMTQLGENHDITLDVSRRIYEAAR

3D structure

• PDB: 1oj7 Crystal Structure of E.Coli Alcohol Dehydrogenase Yqhd: Evidence of a Covalently Modified Nadp Coenzyme
• Chain: C
• Resolution: 2.0 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.2: alcohol dehydrogenase (NADP(+)).

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	ZN	C	D194 H198 H267 H281	D197 H201 H270 H284

Gene Ontology

Molecular Function

• GO:0008106 alcohol dehydrogenase (NADP+) activity
• GO:0008270 zinc ion binding
• GO:0016491 oxidoreductase activity
• GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor
• GO:0018455 alcohol dehydrogenase [NAD(P)+] activity
• GO:0042802 identical protein binding
• GO:0046872 metal ion binding
• GO:1990002 methylglyoxal reductase (NADPH) (acetol producing) activity
• GO:1990362 butanol dehydrogenase (NAD+) activity

Biological Process

• GO:0000302 response to reactive oxygen species

Cellular Component

• GO:0005829 cytosol

External links

• PDB: RCSB:1oj7, PDBe:1oj7, PDBj:1oj7
• PDBsum: 1oj7
• PubMed: 15327949
• UniProt: Q46856|YQHD_ECOLI Alcohol dehydrogenase YqhD (Gene Name=yqhD)