Structure of PDB 1o2a Chain C

Receptor sequence
>1o2aC (length=214) Species: 2336 (Thermotoga maritima) [Search protein sequence]
MKIDILDKGFVELVDVMGNDLSAVRAARVSFDDEERDRHLIEYLMKHGHE
TPFEHIVFTFHVKAPIFVARQWFRHRIASYNELSGRYSSYEFYIPSPERL
EGYKTTIPPERVTEKISEIVDKAYRTYLELIESGVPREVARIVLPLNLYT
RFFWTVNARSLMNFLNLRADSHAQWEIQQYALAIARIFKEKCPWTFEAFL
KYAYKGDILKEVQV
3D structure
PDB1o2a Functional Analysis of Substrate and Cofactor Complex Structures of a Thymidylate Synthase-Complementing Protein
ChainC
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.1.1.148: thymidylate synthase (FAD).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 FAD C E58 I81 N163 R165 E54 I77 N157 R159
BS02 FAD C N85 E86 N81 E82
BS03 FAD C R78 H79 R80 I81 N169 L173 R174 H178 R74 H75 R76 I77 N163 L167 R168 H172
Gene Ontology
Molecular Function
GO:0004799 thymidylate synthase activity
GO:0008168 methyltransferase activity
GO:0050660 flavin adenine dinucleotide binding
GO:0050797 thymidylate synthase (FAD) activity
GO:0070402 NADPH binding
Biological Process
GO:0006231 dTMP biosynthetic process
GO:0006235 dTTP biosynthetic process
GO:0009165 nucleotide biosynthetic process
GO:0032259 methylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1o2a, PDBe:1o2a, PDBj:1o2a
PDBsum1o2a
PubMed12791256
UniProtQ9WYT0|THYX_THEMA Flavin-dependent thymidylate synthase (Gene Name=thyX)

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