Structure of PDB 1n8p Chain C

Receptor sequence
>1n8pC (length=393) Species: 4932 (Saccharomyces cerevisiae) [Search protein sequence]
TLQESDKFATKAIHAGEHVDVHGSVIEPISLSTTFKQSSPANPIGTYEYS
RSQNPNRENLERAVAALENAQYGLAFSSGSATTATILQSLPQGSHAVSIG
DVYGGTHRYFTKVANAHGVETSFTNDLLNDLPQLIKENTKLVWIETPTNP
TLKVTDIQKVADLIKKHAAGQDVILVVDNTFLSPYISNPLNFGADIVVHS
ATKYINGHSDVVLGVLATNNKPLYERLQFLQNAIGAIPSPFDAWLTHRGL
KTLHLRVRQAALSANKIAEFLAADKENVVAVNYPGLKTHPNYDVVLKQHR
DALGGGMISFRIKGGAEAASKFASSTRLFTLAESLGGIESLLEVPAVMTH
GGIPKEAREASGVFDDLVRISVGIEDTDDLLEDIKQALKQATN
3D structure
PDB1n8p Determinants of Enzymatic Specificity in the Cys-Met-Metabolism PLP-Dependent Enzymes Family: Crystal Structure of Cystathionine gamma-lyase from Yeast and Intrafamiliar Structural Comparison
ChainC
Resolution2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R51 Y103 D178 K203
Catalytic site (residue number reindexed from 1) R51 Y103 D178 K203
Enzyme Commision number 4.4.1.1: cystathionine gamma-lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 PLP C S78 G79 S80 Y103 D178 F181 S200 K203 S78 G79 S80 Y103 D178 F181 S200 K203
Gene Ontology
Molecular Function
GO:0004123 cystathionine gamma-lyase activity
GO:0016829 lyase activity
GO:0030170 pyridoxal phosphate binding
GO:0044540 L-cystine L-cysteine-lyase (deaminating)
GO:0047804 cysteine-S-conjugate beta-lyase activity
GO:0080146 L-cysteine desulfhydrase activity
Biological Process
GO:0019343 cysteine biosynthetic process via cystathionine
GO:0019344 cysteine biosynthetic process
GO:0019346 transsulfuration
GO:1904828 positive regulation of hydrogen sulfide biosynthetic process
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm

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Cellular Component
External links
PDB RCSB:1n8p, PDBe:1n8p, PDBj:1n8p
PDBsum1n8p
PubMed12715888
UniProtP31373|CYS3_YEAST Cystathionine gamma-lyase (Gene Name=CYS3)

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