Structure of PDB 1mxh Chain C

Receptor sequence
>1mxhC (length=248) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
CPAAVITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAAR
AGSAVLCKGDLSLSSSLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPL
LPPIDAQVAELFGSNAVAPLFLIRAFARRQSRNLSVVNLCDAMTDLPLPG
FCVYTMAKHALGGLTRAAALELAPRHIRVNAVAPGLSLLPPAMPQETQEE
YRRKVPLGQSEASAAQIADAIAFLVSKDAGYITGTTLKVDGGLILARA
3D structure
PDB1mxh Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor.
ChainC
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R22 D169 Y182 K186
Catalytic site (residue number reindexed from 1) R12 D141 Y154 K158
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NAP C R22 I23 Y42 R43 H44 S45 L71 N101 A102 S103 A104 L167 C168 K186 P212 G213 S215 L216 R12 I13 Y32 R33 H34 S35 L61 N91 A92 S93 A94 L139 C140 K158 P184 G185 S187 L188
BS02 DHF C S103 Y105 F179 Y182 P218 M221 S93 Y95 F151 Y154 P190 M193
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:1mxh, PDBe:1mxh, PDBj:1mxh
PDBsum1mxh
PubMed16168672
UniProtQ8I814

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