Structure of PDB 1mxf Chain C

Receptor sequence
>1mxfC (length=247) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
CPAAVITGGARRIGHSIAVRLHQQGFRVVVHYRHSEGAAQRLVAELNAAR
AGSAVLCKGDLSLSSSLLDCCEDIIDCSFRAFGRCDVLVNNASAYYPTPL
LPKPIDAQVAELFGSNAVAPLFLIRAFARRQNLSVVNLCDAMTDLPLPGF
CVYTMAKHALGGLTRAAALELAPRHIRVNAVAPGLSLLPPAMPQETQEEY
RRKVPLGQSEASAAQIADAIAFLVSKDAGYITGTTLKVDGGLILARA
3D structure
PDB1mxf Crystal structure of Trypanosoma cruzi pteridine reductase 2 in complex with a substrate and an inhibitor.
ChainC
Resolution2.3 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) R22 D169 Y182 K186
Catalytic site (residue number reindexed from 1) R12 D140 Y153 K157
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NDP C R22 I23 R43 H44 S45 D70 L71 N101 A102 S103 L167 K186 P212 G213 S215 R12 I13 R33 H34 S35 D60 L61 N91 A92 S93 L138 K157 P183 G184 S186
BS02 MTX C R22 S103 Y105 Y182 Y229 R12 S93 Y95 Y153 Y200
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0016491 oxidoreductase activity

View graph for
Molecular Function
External links
PDB RCSB:1mxf, PDBe:1mxf, PDBj:1mxf
PDBsum1mxf
PubMed16168672
UniProtQ8I814

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