Structure of PDB 1m1d Chain C

Receptor sequence
>1m1dC (length=162) Species: 5911 (Tetrahymena thermophila) [Search protein sequence]
LDFDILTNDGTHRNMKLLIDLKNIFSRQLPKMPKEYIVKLVFDRHHESMV
ILKNKQKVIGGICFRQYKPQRFAEVAFLAVTANEQVRGYGTRLMNKFKDH
MQKQNIEYLLTYADNFAIGYFKKQGFTKEHRMPQEKWKGYIKDYDGGTLM
ECYIHPYVDYGR
3D structure
PDB1m1d Structure of the GCN5 histone acetyltransferase bound to a bisubstrate inhibitor.
ChainC
Resolution2.2 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Y415 F420 E422 V423 A424 L426 L458 I489 Y492
Catalytic site (residue number reindexed from 1) Y67 F72 E74 V75 A76 L78 L110 I141 Y144
Enzyme Commision number 2.3.1.48: histone acetyltransferase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C Q376 L377 V423 L426 A427 V428 Q433 V434 G436 G438 T459 Y460 D462 F464 G467 Y468 F469 G495 Q28 L29 V75 L78 A79 V80 Q85 V86 G88 G90 T111 Y112 D114 F116 G119 Y120 F121 G147
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
GO:0016747 acyltransferase activity, transferring groups other than amino-acyl groups

View graph for
Molecular Function
External links
PDB RCSB:1m1d, PDBe:1m1d, PDBj:1m1d
PDBsum1m1d
PubMed12391296
UniProtQ27198

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