Structure of PDB 1lvc Chain C

Receptor sequence
>1lvcC (length=503) Species: 1392 (Bacillus anthracis) [Search protein sequence]
RIDVLKGEKALKASGLVPEHADAFKKIARELNTYILFRPVNKLATNLIKS
GVATKGLNVHGKSSDWGPVAGYIPFDQDLSKKHGQQLAVEKGNLENKKSI
TEHEGEIGKIPLKLDHLRIEELKENGIILKGKKEIDNGKKYYLLESNNQV
YEFRISDENNEVQYKTKEGKITVLGEKFNWRNIEVMAKNVEGVLKPLTAD
YDLFALAPSLTEIKKQIPQKEWDKVVNTPNSLEKQKGVTNLLIKYGIERK
PDSTKGTLSNWQKQMLDRLNEAVKYTGYTGGDVVNHGTEQDNEEFPEKDN
EIFIINPEGEFILTKNWEMTGRFIEKNITGKDYLYYFNRSYNKIAPGNKA
YIEWTDPITKAKINTIPTSAEFIKNLSSIRRSSNVGVYKDSGDKDEFAKK
ESVKKIAGYLSDYYNSANHIFSQEKKRKISIFRGIQAYNEIENVLKSKQI
APEYKNYFQYLKERITNQVQLLLTHQKFKLLYKQLNFTENETDNFEVFQK
IID
3D structure
PDB1lvc Physiological calcium concentrations regulate calmodulin binding and catalysis of adenylyl cyclase exotoxins
ChainC
Resolution3.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 4.6.1.1: adenylate cyclase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 DOT C K346 H351 S354 K382 E386 D493 H577 N583 F586 K55 H60 S63 K91 E95 D202 H286 N292 F295
Gene Ontology
Molecular Function
GO:0008294 calcium- and calmodulin-responsive adenylate cyclase activity
Cellular Component
GO:0005576 extracellular region

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Molecular Function
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Cellular Component
External links
PDB RCSB:1lvc, PDBe:1lvc, PDBj:1lvc
PDBsum1lvc
PubMed12485993
UniProtP40136|CYAA_BACAN Calmodulin-sensitive adenylate cyclase (Gene Name=cya)

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