Structure of PDB 1kya Chain C

Receptor sequence

>1kyaC (length=499) Species: 5325 (Trametes versicolor)

GIGPVADLTITNAAVSPDGFSRQAVVVNGGTPGPLITGNMGDRFQLNVID
NLTNHTMLKSTSIHWHGFFQKGTNWADGPAFINQCPISSGHSFLYDFQVP
DQAGTFWYHSHLSTQYCDGLRGPFVVYDPNDPAADLYDVDNDDTVITLVD
WYHVAAKLGPAFPLGADATLINGKGRSPSTTTADLSVISVTPGKRYRFRL
VSLSCDPNYTFSIDGHNMTIIETDSINTAPLVVDSIQIFAAQRYSFVLEA
NQAVDNYWIRANPNFGNVGFTGGINSAILRYDGAAAVEPTTTQTTSTAPL
NEVNLHPLVATAVPGSPVAGGVDLAINMAFNFNGTNFFINGASFTPPTVP
VLLQIISGAQNAQDLLPSGSVYSLPSNADIEISFPATAAAPGAPHPFHLH
GHAFAVVRSAGSTVYNYDNPIFRDVVSTGTPAAGDNVTIRFRTDNPGPWF
LHCHIDFHLEAGFAVVFAEDIPDVASANPVPQAWSDLCPTYDARDPSDQ

3D structure

• PDB: 1kya Crystal structure of a four-copper laccase complexed with an arylamine: insights into substrate recognition and correlation with kinetics.
• Chain: C
• Resolution: 2.4 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): H64 H66 H109 H111 H395 H398 H400 H452 C453 H454 I455 H458 F463
• Catalytic site (residue number reindexed from 1): H64 H66 H109 H111 H395 H398 H400 H452 C453 H454 I455 H458 F463
• Enzyme Commision number: 1.10.3.2: laccase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	CU	C	H395 C453 H458	H395 C453 H458
BS02	CU	C	H111 H400 H452	H111 H400 H452
BS03	CU	C	H66 H109 H454	H66 H109 H454
BS04	CU	C	H64 H398 H400	H64 H398 H400
BS05	XYD	C	F162 L164 D206 F265 G392 H458	F162 L164 D206 F265 G392 H458

Gene Ontology

Molecular Function

• GO:0005507 copper ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0052716 hydroquinone:oxygen oxidoreductase activity

Cellular Component

• GO:0005576 extracellular region

External links

• PDB: RCSB:1kya, PDBe:1kya, PDBj:1kya
• PDBsum: 1kya
• PubMed: 12044164
• UniProt: Q96UT7