Structure of PDB 1kkq Chain C

Receptor sequence
>1kkqC (length=269) Species: 9606 (Homo sapiens) [Search protein sequence]
TADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCM
AEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFAN
LDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRK
PFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEK
MQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKK
TESDAALHPLLQEIYRDMY
3D structure
PDB1kkq Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARalpha.
ChainC
Resolution3.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C E212 K216 K292 N303 V306 E13 K17 K93 N104 V107
BS02 471 C I241 I272 F273 C276 Q277 T279 S280 M330 V332 F351 I354 I42 I73 F74 C77 Q78 T80 S81 M131 V133 F152 I155
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1kkq, PDBe:1kkq, PDBj:1kkq
PDBsum1kkq
PubMed11845213
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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