Structure of PDB 1k7l Chain C

Receptor sequence
>1k7lC (length=267) Species: 9606 (Homo sapiens) [Search protein sequence]
DLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAE
KTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLD
LNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPF
CDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQ
EGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTE
SDAALHPLLQEIYRDMY
3D structure
PDB1k7l Structural determinants of ligand binding selectivity between the peroxisome proliferator-activated receptors.
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C L302 Q305 V306 L309 K310 L459 E462 L101 Q104 V105 L108 K109 L258 E261
BS02 peptide C D371 N415 H416 D418 D170 N214 H215 D217
BS03 544 C F273 C275 C276 S280 Y314 L321 M330 V332 F351 I354 M355 H440 Y464 F72 C74 C75 S79 Y113 L120 M129 V131 F150 I153 M154 H239 Y263 BindingDB: EC50=240nM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Biological Process
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Cellular Component
External links
PDB RCSB:1k7l, PDBe:1k7l, PDBj:1k7l
PDBsum1k7l
PubMed11698662
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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