Structure of PDB 1jxq Chain C

Receptor sequence
>1jxqC (length=242) Species: 9606 (Homo sapiens) [Search protein sequence]
MGALESLRGNADLAYILSMEPCGHCLIINNVNFCRESGLRTRTGSNIDCE
KLRRRFSSLHFMVEVKGDLTAKKMVLALLELARQDHGALDCCVVVILSHG
CQASHLQFPGAVYGTDGCPVSVEKIVNIFNGTSCPSLGGKPKLFFIQACG
GEQKDHGFEVLPTPSDIFVSYSTFPGFVSWRDPKSGSWYVETLDDIFEQW
AHSEDLQSLLLRVANAVSVKGIYKQMPGCFNFLRKKLFFKTS
3D structure
PDB1jxq Dimer formation drives the activation of the cell death protease caspase 9.
ChainC
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) R177 T178 H237 G238 C285 G286
Catalytic site (residue number reindexed from 1) R40 T41 H99 G100 C149 G150
Enzyme Commision number 3.4.22.62: caspase-9.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C R179 H237 C285 K290 S339 W340 R341 P343 I382 Y383 R42 H99 C149 K154 S179 W180 R181 P183 I222 Y223
Gene Ontology
Molecular Function
GO:0004197 cysteine-type endopeptidase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:1jxq, PDBe:1jxq, PDBj:1jxq
PDBsum1jxq
PubMed11734640
UniProtP55211|CASP9_HUMAN Caspase-9 (Gene Name=CASP9)

[Back to BioLiP]