Structure of PDB 1jrp Chain C

Receptor sequence

>1jrpC (length=450) Species: 1061 (Rhodobacter capsulatus)

MEIAFLLNGETRRVRIEDPTQSLLELLRAEGLTGTKEGCNEGDCGACTVM
IRDAAGSRAVNACLMMLPQIAGKALRTIEGIAAPDGRLHPVQQAMIDHHG
SQCGFCTPGFIVSMAAAHDRDRKDYDDLLAGNLCRCTGYAPILRAAEAAA
GEPPADWLQADAAFTLPAFLPETSDALADWYLAHPEATLIAGGTDVSLWV
TKALRDLPEVAFLSHCKDLAQIRETPDGYGIGAGVTIAALRAFAEGPHPA
LAGLLRRFASEQVRQVATIGGNIANGSPIGDGPPALIAMGASLTLRRGQE
RRRMPLEDFFLEYRKQDRRPGEFVESVTLPKSAPGLRCYKLSKRFDQDIS
AVCGCLNLTLKGSKIETARIAFGGMAGVPKRAAAFEAALIGQDFREDTIA
AALPLLAQDFTPLSDMRASAAYRMNAAQAMALRYVRELSGEAVAVLEVMP

3D structure

• PDB: 1jrp Crystal structures of the active and alloxanthine-inhibited forms of xanthine dehydrogenase from Rhodobacter capsulatus
• Chain: C
• Resolution: 3.0 Å

Enzymatic activity

• Enzyme Commision number: 1.1.1.204: Transferred entry: 1.17.1.4.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	FES	C	C103 G104 C106 C134 R135 C136	C103 G104 C106 C134 R135 C136
BS02	FES	C	E37 G38 C39 N40 G42 C44 G45 C47 C63	E37 G38 C39 N40 G42 C44 G45 C47 C63
BS03	FAD	C	G42 L201 A203 G204 G205 T206 D207 V208 F270 A271 T280 G283 N284 A286 G292 D293 R330 V336	G42 L189 A191 G192 G193 T194 D195 V196 F258 A259 T268 G271 N272 A274 G280 D281 R318 V324

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0004854 xanthine dehydrogenase activity
• GO:0005506 iron ion binding
• GO:0016491 oxidoreductase activity
• GO:0046872 metal ion binding
• GO:0050660 flavin adenine dinucleotide binding
• GO:0051536 iron-sulfur cluster binding
• GO:0051537 2 iron, 2 sulfur cluster binding
• GO:0071949 FAD binding

External links

• PDB: RCSB:1jrp, PDBe:1jrp, PDBj:1jrp
• PDBsum: 1jrp
• PubMed: 11796116
• UniProt: O54050