Structure of PDB 1jq3 Chain C

Receptor sequence
>1jq3C (length=293) Species: 2336 (Thermotoga maritima) [Search protein sequence]
LKELERELQPRQHLWYFEYYTGNNVGLFMKMNRVIYSGQSDIQRIDIFEN
PDLGVVFALDGITMTTEKDEFMYHEMLAHVPMFLHPNPKKVLIIGGGDGG
TLREVLKHDSVEKAILCEVDGLVIEAARKYLKQTSCGFDDPRAEIVIANG
AEYVRKFKNEFDVIIIDSTDPTAGQGGHLFTEEFYQACYDALKEDGVFSA
ETEDPFYDIGWFKLAYRRISKVFPITRVYLGFMTTYPSGMWSYTFASKGI
DPIKDFDPEKVRKFNKELKYYNEEVHVASFALPNFVKKELGLM
3D structure
PDB1jq3 The crystal structure of spermidine synthase with a multisubstrate adduct inhibitor.
ChainC
Resolution1.8 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.5.1.16: spermidine synthase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AAT C L62 T66 M67 T68 Y76 H77 G98 G99 G100 D101 C120 E121 V122 V126 D170 S171 T172 D173 L182 Y239 L59 T63 M64 T65 Y73 H74 G95 G96 G97 D98 C117 E118 V119 V123 D167 S168 T169 D170 L179 Y236 MOAD: ic50=0.2uM
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004766 spermidine synthase activity
GO:0010487 thermospermine synthase activity
GO:0016740 transferase activity
GO:0043918 cadaverine aminopropyltransferase activity
GO:0043919 agmatine aminopropyltransferase activity
GO:0050314 sym-norspermidine synthase activity
Biological Process
GO:0006596 polyamine biosynthetic process
GO:0008295 spermidine biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1jq3, PDBe:1jq3, PDBj:1jq3
PDBsum1jq3
PubMed11731804
UniProtQ9WZC2|SPEE_THEMA Polyamine aminopropyltransferase (Gene Name=speE)

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