Structure of PDB 1imh Chain C

Receptor sequence
>1imhC (length=281) Species: 9606 (Homo sapiens) [Search protein sequence]
KKSPMLCGQYPVKSEGKELKIVVQPETQHRARYLTEGSRGSVKDRTQQGF
PTVKLEGHNEPVVLQVFVGNDSGRVKPHGFYQACRVTGRNTTPCKEVDIE
GTTVIEVGLDPSNNMTLAVDCVGILKLRNADVEARIGIAGSKKKSTRARL
VFRVNIMRKDGSTLTLQTPSSPILCTQPAGVPEILKKSLHSCSVKGEEEV
FLIGKNFLKGTKVIFQENVSDENSWKSEAEIDMELFHQNHLIVKVPPYHD
QHITLPVSVGIYVVTNAGRSHDVQPFTYTPD
3D structure
PDB1imh Structure of a TonEBP-DNA complex reveals DNA encircled by a transcription factor.
ChainC
Resolution2.86 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 dna C R217 G224 S225 R226 G227 Q364 K392 R30 G37 S38 R39 G40 Q177 K205 PDBbind-CN: Kd=30nM
BS02 dna C Y220 T222 E223 R315 N316 T333 Y33 T35 E36 R128 N129 T146 PDBbind-CN: Kd=30nM
Gene Ontology
Molecular Function
GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:1imh, PDBe:1imh, PDBj:1imh
PDBsum1imh
PubMed11780147
UniProtO94916|NFAT5_HUMAN Nuclear factor of activated T-cells 5 (Gene Name=NFAT5)

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