Structure of PDB 1i6v Chain C

Receptor sequence
>1i6vC (length=1113) Species: 271 (Thermus aquaticus) [Search protein sequence]
KIKRFGRIREVIPLPPLTEIQVESYKKALQADVPPEKRENVGIQAAFKET
FPIEEGDKGKGGLVLDFLEYRIGDPPFSQDECREKDLTYQAPLYARLQLI
HKDTGLIKEDEVFLGHLPLMTEDGSFIINGADRVIVSQIHRSPGVYFTPD
PARPGRYIASIIPLPKRGPWIDLEVEASGVVTMKVNKRKFPLVLLLRVLG
YDQETLVRELSAYGDLVQGLLDEAVLAMRPEEAMVRLFTLLRPGDPPKKD
KALAYLFGLLADPKRYDLGEAGRYKAEEKLGVGLSGRTLVRFEDGEFKDE
VFLPTLRYLFALTAGVPGHEVDDIDHLGNRRIRTVGELMADQFRVGLARL
ARGVRERMVMGSPDTLTPAKLVNSRPLEAALREFFSRSQLSQFKDETNPL
SSLRHKRRISALGPGGLTRERAGFDVRDVHRTHYGRICPVETPEGANIGL
ITSLAAYARVDALGFIRTPYRRVKNGVVTEEVVYMTASEEDRYTIAQANT
PLEGDRIATDRVVARRRGEPVIVAPEEVEFMDVSPKQVFSLNTNLIPFLE
HDDANRALMGSNMQTQAVPLIRAQAPVVMTGLEERVVRDSLAALYAEEDG
EVVKVDGTRIAVRYEDGRLVHPLRRYARSNQGTAFDQRPRVRVGQRVKKG
DLLADGPASEEGFLALGQNVLVAIMPFDGYNFEDAIVISEELLKRDFYTS
IHIERYEIEARDTKLGPERITRDIPHLSEAALRDLDEEGIVRIGAEVKPG
DILVGRTSFKGEQEPSPEERLLRSIFGEKARDVKDTSLRVPPGEGGIVVG
RLRLRRGDPGVELKPGVREVVRVFVAQKRKLQVGDKLANRHGNKGVVAKI
LPVEDMPHLPDGTPVDVILNPLGVPSRMNLGQILETHLGLAGYFLGQRYI
SPVFDGATEPEIKELLAEAFNLYFGKRQGEGFGVDKREKEVLARAEKLGL
VSPGKSPEEQLKELFDLGKVVLYDGRTGEPFEGPIVVGQMFIMKLYHMVE
DKMHARSTGPYSLITQQPLGGKAQFGGQRFGEMEVWALEAYGAAHTLQEM
LTIKSDDIEGRNAAYQAIIKGEDVPEPSVPESFRVLVKELQALALDVQTL
DEKDNPVDVFEGL
3D structure
PDB1i6v Structural mechanism for rifampicin inhibition of bacterial rna polymerase.
ChainC
Resolution3.3 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.7.6: DNA-directed RNA polymerase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 RFP C Q390 S392 Q393 F394 D396 R409 S411 E445 I452 Q389 S391 Q392 F393 D395 R408 S410 E444 I451 PDBbind-CN: -logKd/Ki=5.00,Ki=10uM
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003899 DNA-directed 5'-3' RNA polymerase activity
GO:0016779 nucleotidyltransferase activity
GO:0032549 ribonucleoside binding
GO:0034062 5'-3' RNA polymerase activity
Biological Process
GO:0006351 DNA-templated transcription
Cellular Component
GO:0000428 DNA-directed RNA polymerase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1i6v, PDBe:1i6v, PDBj:1i6v
PDBsum1i6v
PubMed11290327
UniProtQ9KWU7|RPOB_THEAQ DNA-directed RNA polymerase subunit beta (Gene Name=rpoB)

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