Structure of PDB 1gz3 Chain C
Receptor sequence
| >1gz3C (length=554) Species: 9606 (Homo sapiens) [Search protein sequence] |
| HIKEKGKPLMLNPRTNKGMAFTLQERQMLGLQGLLPPKIETQDIQALRFH RNLKKMTSPLEKYIYIMGIQERNEKLFYRILQDDIESLMPIVYTPTVGLA CSQYGHIFRRPKGLFISISDRGHVRSIVDNWPENHVKAVVVTDGERILGL GDLGVYGMGIPVGKLCLYTACAGIRPDQCLPVCIDVGTDNIALLKDPFYM GLYQKRDRTQQYDDLIDEFMKAITDRYGRNTLIQFEDFGNHNAFRFLRKY REKYCTFNDDIQGTAAVALAGLLAAQKVISKPISEHKILFLGAGEAALGI ANLIVMSMVENGLSEQEAQKKIWMFDKYGLLVKGRKAKIDSYQEPFTHSA PESIPDTFEDAVNILKPSTIIGVAGAGRLFTPDVIRAMASINERPVIFAL SNPTAQAECTAEEAYTLTEGRCLFASGSPFGPVKLTDGRVFTPGQGNNVY IFPGVALAVILCNTRHISDSVFLEAAKALTSQLTDEELAQGRLYPPLANI QEVSINIAIKVTEYLYANKMAFVYPEPEDKAKYVKEQTWRSEYDSLLPDV YEWP |
3D structure
| PDB | 1gz3 Molecular Mechanism for the Regulation of Human Mitochondrial Nad(P)+-Dependent Malic Enzyme by ATP and Fumarate | ||
| Chain | C | ||
| Resolution | 2.3 Å | ||
| 3D structure |
|
Enzymatic activity
| Catalytic site (original residue number in PDB) | Y112 R165 K183 E255 D256 D278 D279 N421 |
| Catalytic site (residue number reindexed from 1) | Y93 R146 K164 E236 D237 D259 D260 N402 |
| Enzyme Commision number | 1.1.1.38: malate dehydrogenase (oxaloacetate-decarboxylating). |
Interaction with ligand
| Site # |
Ligand | Ligand chain |
Binding residues on receptor (original residue number in PDB) |
Binding residues on receptor (residue number reindexed from 1) |
Binding affinity |
|---|---|---|---|---|---|
| BS01 | ATP | C | R165 N259 G311 A312 G313 E314 D345 K346 V392 A393 G394 | R146 N240 G292 A293 G294 E295 D326 K327 V373 A374 G375 | MOAD: Ki=0.2mM |
| BS02 | OXL | C | R165 L167 K183 D279 N421 N467 | R146 L148 K164 D260 N402 N448 | |
| BS03 | MN | C | E255 D256 D279 | E236 D237 D260 | |
| BS04 | FUM | C | Q64 R67 R91 | Q45 R48 R72 |
Gene Ontology
| Molecular Function | |
|---|---|
| GO:0004470 | malic enzyme activity |
| GO:0004471 | malate dehydrogenase (decarboxylating) (NAD+) activity |
| GO:0004473 | malate dehydrogenase (decarboxylating) (NADP+) activity |
| GO:0008948 | oxaloacetate decarboxylase activity |
| GO:0009055 | electron transfer activity |
| GO:0016491 | oxidoreductase activity |
| GO:0016616 | oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor |
| GO:0046872 | metal ion binding |
| GO:0051287 | NAD binding |
