Structure of PDB 1gmy Chain C

Receptor sequence
>1gmyC (length=253) Species: 9606 (Homo sapiens) [Search protein sequence]
KLPASFDAREQWPQCPTIKEIRDQGSCGSCWAFGAVEAISDRICIHTNAH
VSVEVSAEDLLTCCGSMCGDGCNGGYPAEAWNFWTRKGLVSGGLYESHVG
CRPYSIPPCEHHVNGSRPPCTGEGDTPKCSKICEPGYSPTYKQDKHYGYN
SYSVSNSEKDIMAEIYKNGPVEGAFSVYSDFLLYKSGVYQHVTGEMMGGH
AIRILGWGVENGTPYWLVANSWNTDWGDNGFFKILRGQDHCGIESEVVAG
IPR
3D structure
PDB1gmy Identification of Dipeptidyl Nitriles as Potent and Selective Inhibitors of Cathepsin B Through Structure-Based Drug Design
ChainC
Resolution1.9 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q23 C29 H199 N219
Catalytic site (residue number reindexed from 1) Q24 C30 H200 N220
Enzyme Commision number 3.4.22.1: cathepsin B.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 AEM C G27 C29 G28 C30
BS02 APD C C29 W30 G73 G74 A173 G198 E245 C30 W31 G74 G75 A174 G199 E246
BS03 DFA C N72 G73 G74 Y75 N73 G74 G75 Y76
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1gmy, PDBe:1gmy, PDBj:1gmy
PDBsum1gmy
PubMed11741472
UniProtP07858|CATB_HUMAN Cathepsin B (Gene Name=CTSB)

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