Structure of PDB 1ggf Chain C

Receptor sequence
>1ggfC (length=727) Species: 562 (Escherichia coli) [Search protein sequence]
DSLAPEDGSHRPAAEPTPPGAQPTAPGSLKAPDTRNEKLNSLEDVRKGSE
NYALTTNQGVRIADDQNSLRAGSRGPTLLEDFILREKITHFDHERIPERI
VNARGSAAHGYFQPYKSLSDITKADFLSDPNKITPVFVRFSTVQGGAGSA
DTVRDIRGFATKFYTEEGIFDLVGNNTPIFFIQDAHKFPDFVHAVKPEPH
WAIPQGQSAHDTFWDYVSLQPETLHNVMWAMSDRGIPRSYRTMEGFGIHT
FRLINAEGKATFVRFHWKPLAGKASLVWDEAQKLTGRDPDFHRRELWEAI
EAGDFPEYELGFQLIPEEDEFKFDFDLLDPTKLIPEELVPVQRVGKMVLN
RNPDNFFAENEQAAFHPGHIVPGLDFTNDPLLQGRLFSYTDTQISRLGGP
NFHEIPINRPTCPYHNFQRDGMHRMGIDTNPANYEPNSINDNWPRETPPG
PKRGGFESYQERVEGNKVRERSPSFGEYYSHPRLFWLSQTPFEQRHIVDG
FSFELSKVVRPYIRERVVDQLAHIDLTLAQAVAKNLGIELTDDQLNITPP
PDVNGLKKDPSLSLYAIPDGDVKGRVVAILLNDEVRSADLLAILKALKAK
GVHAKLLYSRMGEVTADDGTVLPIAATFAGAPSLTVDAVIVPCGNIADIA
DNGDANYYLMEAYKHLKPIALAGDARKFKATIKIADQGEEGIVEADSADG
SFMDELLTLMAAHRVWSRIPKIDKIPA
3D structure
PDB1ggf Substrate flow in catalases deduced from the crystal structures of active site variants of HPII from Escherichia coli.
ChainC
Resolution2.28 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) N128 N201 H392
Catalytic site (residue number reindexed from 1) N102 N175 H366
Enzyme Commision number 1.11.1.6: catalase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HEM C V127 N128 R165 V199 N201 F214 I274 H275 F391 L407 R411 S414 Y415 T418 Q419 R422 V101 N102 R139 V173 N175 F188 I248 H249 F365 L381 R385 S388 Y389 T392 Q393 R396
BS02 PEO C N128 V169 N201 N102 V143 N175
BS03 PEO C Q233 A235 E530 Q207 A209 E504
Gene Ontology
Molecular Function
GO:0004096 catalase activity
GO:0004601 peroxidase activity
GO:0005506 iron ion binding
GO:0020037 heme binding
GO:0042802 identical protein binding
GO:0046872 metal ion binding
Biological Process
GO:0006972 hyperosmotic response
GO:0006974 DNA damage response
GO:0006979 response to oxidative stress
GO:0042744 hydrogen peroxide catabolic process
GO:0098869 cellular oxidant detoxification
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1ggf, PDBe:1ggf, PDBj:1ggf
PDBsum1ggf
PubMed11455600
UniProtP21179|CATE_ECOLI Catalase HPII (Gene Name=katE)

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