Structure of PDB 1f7b Chain C

Receptor sequence
>1f7bC (length=285) Species: 727 (Haemophilus influenzae) [Search protein sequence]
MRDLKGIFSALLVSFNEDGTINEKGLRQIIRHNIDKMKVDGLYVGGSTGE
NFMLSTEEKKEIFRIAKDEAKDQIALIAQVGSVNLKEAVELGKYATELGY
DCLSAVTPFYYKFSFPEIKHYYDTIIAETGSNMIVYSMGIEQFGELYKNP
KVLGVKFTAGDFYLLERLKKAYPNHLIWAGFDEMMLPAASLGVDGAIGST
FNVNGVRARQIFELTKAGKLKEALEIQHVTNDLIEGILANGLYLTIKELL
KLEGVDAGYCREPMTSKATAEQVAKAKDLKAKFLS
3D structure
PDB1f7b Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
ChainC
Resolution1.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S47 Y110
Catalytic site (residue number reindexed from 1) S47 Y110
Enzyme Commision number 4.1.3.3: N-acetylneuraminate lyase.
Interaction with ligand
Site
#
Ligand Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01 NAV C Y43 G46 S47 T48 K164 G188 F189 D190 E191 G206 S207 L250 Y43 G46 S47 T48 K156 G180 F181 D182 E183 G198 S199 L242 PDBbind-CN: -logKd/Ki=4.60,Ki=0.025mM
Gene Ontology
Molecular Function
GO:0008747 N-acetylneuraminate lyase activity
GO:0016829 lyase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0019262 N-acetylneuraminate catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function

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Biological Process

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Cellular Component
External links
PDB RCSB:1f7b, PDBe:1f7b, PDBj:1f7b
PDBsum1f7b
PubMed11031117
UniProtP44539|NANA_HAEIN N-acetylneuraminate lyase (Gene Name=nanA)

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