Structure of PDB 1f73 Chain C

Receptor sequence
>1f73C (length=288) Species: 727 (Haemophilus influenzae) [Search protein sequence]
MRDLKGIFSALLVSFNEDGTINEKGLRQIIRHNIDKMKVDGLYVGGSTGE
NFMLSTEEKKEIFRIAKDEAKDQIALIAQVGSVNLKEAVELGKYATELGY
DCLSAVTPFYYKFSFPEIKHYYDTIIAETGSNMIVYSIPNMGIEQFGELY
KNPKVLGVKFTAGDFYLLERLKKAYPNHLIWAGFDEMMLPAASLGVDGAI
GSTFNVNGVRARQIFELTKAGKLKEALEIQHVTNDLIEGILANGLYLTIK
ELLKLEGVDAGYCREPMTSKATAEQVAKAKDLKAKFLS
3D structure
PDB1f73 Active site modulation in the N-acetylneuraminate lyase sub-family as revealed by the structure of the inhibitor-complexed Haemophilus influenzae enzyme.
ChainC
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) S47 Y110 Y136 K164 I205
Catalytic site (residue number reindexed from 1) S47 Y110 Y136 K159 I200
Enzyme Commision number 4.1.3.3: N-acetylneuraminate lyase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 HMN C A10 G46 S47 T48 K164 G188 D190 E191 G206 S207 L250 A10 G46 S47 T48 K159 G183 D185 E186 G201 S202 L245 MOAD: Ki=4.1mM
PDBbind-CN: -logKd/Ki=2.39,Ki=4.1mM
Gene Ontology
Molecular Function
GO:0008747 N-acetylneuraminate lyase activity
GO:0016829 lyase activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0019262 N-acetylneuraminate catabolic process
Cellular Component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:1f73, PDBe:1f73, PDBj:1f73
PDBsum1f73
PubMed11031117
UniProtP44539|NANA_HAEIN N-acetylneuraminate lyase (Gene Name=nanA)

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