Structure of PDB 1f29 Chain C

Receptor sequence
>1f29C (length=215) Species: 5693 (Trypanosoma cruzi) [Search protein sequence]
APAAVDWRARGAVTAVKDQGQCGSCWAFSAIGNVECQWFLAGHPLTNLSE
QMLVSCDKTDSGCSGGLMNNAFEWIVQENNGAVYTEDSYPYASGEGISPP
CTTSGHTVGATITGHVELPQDEAQIAAWLAVNGPVAVAVDASSWMTYTGG
VMTSCVSEQLDHGVLLVGYNDSAAVPYWIIKNSWTTQWGEEGYIRIAKGS
NQCLVKEEASSAVVG
3D structure
PDB1f29 A target within the target: probing cruzain's P1' site to define structural determinants for the Chagas' disease protease.
ChainC
Resolution2.15 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) Q19 C25 H159 N175
Catalytic site (residue number reindexed from 1) Q19 C25 H162 N182
Enzyme Commision number 3.4.22.51: cruzipain.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 VS1 C G23 C25 S64 G65 G66 L67 A133 A136 M142 D158 H159 W177 G23 C25 S64 G65 G66 L67 A138 A141 M145 D161 H162 W184
Gene Ontology
Molecular Function
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1f29, PDBe:1f29, PDBj:1f29
PDBsum1f29
PubMed10997902
UniProtP25779|CYSP_TRYCR Cruzipain

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