Structure of PDB 1esq Chain C

Receptor sequence
>1esqC (length=274) Species: 1423 (Bacillus subtilis) [Search protein sequence]
MRGSHHHHHHGSMDAQSAAKCLTAVRRHSPLVHSITNNVVTNFTANGLLA
LGASPVMAYAKEEVADMAKIAGALVLNIGTLSKESVEAMIIAGKSANEHG
VPVILDPVGAGATPFRTESARDIIREVRLAAIRGNAAEIAHTVGVTDWLG
DIIRLAQQAAQKLNTVIAITGEVDVIADTSHVYTLHNGHKLLTKVTGAGS
LLTSVVGAFCAVEENPLFAAIAAISSYGVAAQLAAQQTADKGPGSFQIEL
LNKLSTVTEQDVQEWATIERVTVS
3D structure
PDB1esq Crystal structure of 4-methyl-5-beta-hydroxyethylthiazole kinase from Bacillus subtilis at 1.5 A resolution.
ChainC
Resolution2.5 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 2.7.1.50: hydroxyethylthiazole kinase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 TZP C P43 V44 M45 P55 V56 M57
BS02 ATP C R121 T168 G169 E170 D172 G186 H187 L190 R133 T170 G171 E172 D174 G188 H189 L192
BS03 TZP C N25 G67 G195 G197 S198 N37 G79 G197 G199 S200
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0004417 hydroxyethylthiazole kinase activity
GO:0005524 ATP binding
GO:0016301 kinase activity
GO:0046872 metal ion binding
Biological Process
GO:0009058 biosynthetic process
GO:0009228 thiamine biosynthetic process
GO:0009229 thiamine diphosphate biosynthetic process
GO:0016310 phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:1esq, PDBe:1esq, PDBj:1esq
PDBsum1esq
PubMed10891066
UniProtP39593|THIM_BACSU Hydroxyethylthiazole kinase (Gene Name=thiM)

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