Structure of PDB 1efa Chain C

Receptor sequence
>1efaC (length=286) Species: 562 (Escherichia coli) [Search protein sequence]
NYIPNRVAQQLAGKQSLLIGVATSSLALHAPSQIVAAIKSRADQLGASVV
VSMVERSGVEACKTAVHNLLAQRVSGLIINYPLDDQDAIAVEAACTNVPA
LFLDVSDQTPINSIIFSHEDGTRLGVEHLVALGHQQIALLAGPLSSVSAR
LRLAGWHKYLTRNQIQPIAEREGDWSAMSGFQQTMQMLNEGIVPTAMLVA
NDQMALGAMRAITESGLRVGADISVVGYDDTEDSSCYIPPLTTIKQDFRL
LGQTSVDRLLQLSQGQAVKGNQLLPVSLVKRKTTLA
3D structure
PDB1efa A closer view of the conformation of the Lac repressor bound to operator.
ChainC
Resolution2.6 Å
3D
structure
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Enzymatic activity
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 NPF C L73 A75 D149 F161 S193 R197 W220 N246 D274 F293 L28 A30 D104 F116 S148 R152 W175 N201 D229 F248
Gene Ontology
Molecular Function
GO:0000976 transcription cis-regulatory region binding
GO:0000987 cis-regulatory region sequence-specific DNA binding
GO:0001217 DNA-binding transcription repressor activity
GO:0003677 DNA binding
GO:0003700 DNA-binding transcription factor activity
GO:0042802 identical protein binding
Biological Process
GO:0006355 regulation of DNA-templated transcription
GO:0045892 negative regulation of DNA-templated transcription
Cellular Component
GO:0005829 cytosol

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Cellular Component
External links
PDB RCSB:1efa, PDBe:1efa, PDBj:1efa
PDBsum1efa
PubMed10700279
UniProtP03023|LACI_ECOLI Lactose operon repressor (Gene Name=lacI)

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