Structure of PDB 1e61 Chain C

Receptor sequence

>1e61C (length=767) Species: 1061 (Rhodobacter capsulatus)

LANGTVMSGSHWGVFTATVENGRATAFTPWEKDPHPSPMLAGVLDSIYSP
TRIKYPMVRREFLEKGVNADRSTRGNGDFVRVSWDQALDLVAAEVKRVEE
TYGPEGVFGGSYGWKSPGRLHNCTTLLRRMLTLAGGYVNGAGDYSTGAAQ
VIMPHVVGTLEVYEQQTAWPVLAENTEVMVFWAADPIKTSQIGWVIPEHG
AYPGLEALKAKGTKVIVIDPVRTKTVEFFGAEHITPKPQTDVAIMLGMAH
TLVAEDLYDKDFIANYTSGFDKFLPYLDGETDSTPKTAEWAEGISGVPAE
TIKELARLFESKRTMLAAGWSMQRMHHGEQAHWMLVTLASMLGQIGLPGG
GFGLSYHYSGGGTPSTSGPALAGITDGGGASVIPVARVVDMLENPGAEFD
FNGTRSKFPDVKMAYWVGGNPFVHHQDRNRMVKAWEKLETFVVHDFQWTP
TARHADIVLPATTSYERNDIETIGDYSNTGILAMKKIVEPLYEARSDYDI
FAAVAERLGKGAEFTEGKDEMGWIKSFYDDAAKQGKAAGVEMPAFDAFWA
EGIVEFPVTDGADFVRYASFREDPLLNPLGTPTGLIEIYSKNIEKMGYDD
CPAHPTWMEPLERLDGPGAKYPLHIAASHPFNRLHSQLNGTVLREGYAVQ
GHEPCLMHPDDAAARGIADGDVVRVHNDRGQILTGVKVTDAVMKGVIQIY
EGGWYDPSDVTEPGTLDKYGDVNVLSADIGTSKLAQGNCGQTVLAEVEKY
TGPAVTLTGFVAPKAAE

3D structure

• PDB: 1e61 Reversible Dissociation of Thiolate Ligands from Molybdenum in an Enzyme of the Dimethyl Sulfoxide Reductase Family
• Chain: C
• Resolution: 1.9 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): M41 W116 S147 T148 V153 I154 W322 S357 Y358 H359 Y360
• Catalytic site (residue number reindexed from 1): M39 W114 S145 T146 V151 I152 W320 S355 Y356 H357 Y358
• Enzyme Commision number: 1.7.2.3: trimethylamine-N-oxide reductase.
  1.8.5.3: respiratory dimethylsulfoxide reductase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	PGD	C	Y114 G115 W116 K117 S118 Y146 S147 R326 G432 G433 N434 H438 H458 D459 F460 D511 A641 H643 H649 S650 Q651 E715 N737	Y112 G113 W114 K115 S116 Y144 S145 R324 G418 G419 N420 H424 H444 D445 F446 D497 A627 H629 H635 S636 Q637 E701 N723
BS02	PGD	C	W116 S147 A185 K190 T191 I194 I220 D221 P222 P240 D243 G321 W322 S323 R326 M327 H359 S642 H643 P644 L648 H649 Q755	W114 S145 A183 K188 T189 I192 I218 D219 P220 P238 D241 G319 W320 S321 R324 M325 H357 S628 H629 P630 L634 H635 Q741
BS03	2MO	C	W116 S147	W114 S145

Gene Ontology

Molecular Function

• GO:0016491 oxidoreductase activity
• GO:0043546 molybdopterin cofactor binding

External links

• PDB: RCSB:1e61, PDBe:1e61, PDBj:1e61
• PDBsum: 1e61
• PubMed: 10985771
• UniProt: Q52675|DSTOR_RHOCA Dimethyl sulfoxide/trimethylamine N-oxide reductase (Gene Name=dorA)