Structure of PDB 1d7w Chain C

Receptor sequence

>1d7wC (length=466) Species: 9606 (Homo sapiens)

VNCETSCVQQPPCFPLKIPPNDPRIKNQADCIPFFRSCPACPGSNITIRN
QINALTSFVDASMVYGSEEPLARNLRNMSNQLGLLAVNQRFQDNGRALLP
FDNLHDDPCLLTNRSARIPCFLAGDTRSSEMPELTSMHTLLLREHNRLAT
ELKSLNPRWDGERLYQEARKIVGAMVQIITYRDYLPLVLGPTAMRKYLPT
YRSYNDSVDPRIANVFTNAFRYGHTLIQPFMFRLDNRYQPMEPNPRVPLS
RVFFASWRVVLEGGIDPILRGLMATPAKLNRQNQIAVDEIRERLFEQVMR
IGLDLPALNMQRSRDHGLPGYNAWRRFCGLPQPETVGQLGTVLRNLKLAR
KLMEQYGTPNNIDIWMGGVSEPLKRKGRVGPLLACIIGTQFRKLRDGDRF
WWENEGVFSMQQRQALAQISLPRIICDNTGITTVSKNNIFMSNSYPRDFV
NCSTLPALNLASWREA

3D structure

• PDB: 1d7w Human myeloperoxidase: structure of a cyanide complex and its interaction with bromide and thiocyanate substrates at 1.9 A resolution.
• Chain: C
• Resolution: 1.9 Å

Enzymatic activity

• Catalytic site (original residue number in PDB): R239
• Catalytic site (residue number reindexed from 1): R127
• Enzyme Commision number: 1.11.2.2: myeloperoxidase.

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	MAN	C	F439 K505	F327 K393
BS02	BR	C	N326 V327 W436	N214 V215 W324
BS03	HEM	C	E242 M243 T329 R333 G335 H336 I339 F365 F407 L417 R424	E130 M131 T217 R221 G223 H224 I227 F253 F295 L305 R312
BS04	CA	C	T168 F170 D172 S174	T56 F58 D60 S62
BS05	BR	C	N348 I543 T544	N236 I431 T432
BS06	BR	C	N200 F213	N88 F101

Gene Ontology

Molecular Function

• GO:0004601 peroxidase activity
• GO:0020037 heme binding

Biological Process

• GO:0006979 response to oxidative stress

External links

• PDB: RCSB:1d7w, PDBe:1d7w, PDBj:1d7w
• PDBsum: 1d7w
• PubMed: 11705390
• UniProt: P05164|PERM_HUMAN Myeloperoxidase (Gene Name=MPO)