Structure of PDB 1cmx Chain C

Receptor sequence
>1cmxC (length=210) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence]
AVVPIESNPEVFTNFAHKLGLKNEWAYFDIYSLTEPELLAFLPRPVKAIV
LLFPVIWFKQSVKNACGLYAILHSLSNNQSLLEPGSDLDNFLKSQSDTSS
SKNRFDDVTTDQFVLNVIKENVQTFSTGQSEAPEATADTNLHYITYVEEN
GGIFELDGRNLSGPLYLGKSDPTATDLIEQELVRVRVASYMENANEEDVL
NFAMLGLGPN
3D structure
PDB1cmx Structural basis for the specificity of ubiquitin C-terminal hydrolases.
ChainC
Resolution2.25 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) Q484 C490 H566 D581
Catalytic site (residue number reindexed from 1) Q60 C66 H142 D157
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 peptide C P410 I411 E412 S413 N414 P415 D435 Y437 L458 N488 C490 Q553 S554 P557 T563 L565 Y567 M615 N619 L624 N625 F626 P4 I5 E6 S7 N8 P9 D29 Y31 L52 N64 C66 Q129 S130 P133 T139 L141 Y143 M191 N195 L200 N201 F202
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
GO:0006511 ubiquitin-dependent protein catabolic process
GO:0010992 ubiquitin recycling
GO:0016579 protein deubiquitination
Cellular Component
GO:0005737 cytoplasm

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1cmx, PDBe:1cmx, PDBj:1cmx
PDBsum1cmx
PubMed10406793
UniProtP35127|UBL1_YEAST Ubiquitin carboxyl-terminal hydrolase YUH1 (Gene Name=YUH1)

[Back to BioLiP]