Structure of PDB 1cjv Chain C

Receptor sequence
>1cjvC (length=329) Species: 9913 (Bos taurus) [Search protein sequence]
ATHRLLLLGAGESGKSTIVKQMRILHVEKATKVQDIKNNLKEAIETIVAA
MSNLVPPVELANPENQFRVDYILSVMNVPDFDFPPEFYEHAKALWEDEGV
RACYERSNEYQLIDCAQYFLDKIDVIKQDDYVPSDQDLLRCRVLTSGIFE
TKFQVDKVNFHMFDVGGQRDERRKWIQCFNDVTAIIFVVASSSYNMVIRE
DNQTNRLQEALNLFKSIWNNRWLRTISVILFLNKQDLLAEKVLAGKSKIE
DYFPEFARYTTPEDATPEPGEDPRVTRAKYFIRDEFLRISTASGDGRHYC
YPHFTCAVDTENIRRVFNDCRDIIQRMHL
3D structure
PDB1cjv Two-metal-Ion catalysis in adenylyl cyclase.
ChainC
Resolution3.0 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) E50 T55 R201 D223 Q227
Catalytic site (residue number reindexed from 1) E12 T17 R142 D164 Q168
Enzyme Commision number ?
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 MG C S54 T204 S16 T145
BS02 ZN C R42 E209 H220 R4 E150 H161
BS03 GSP C G49 E50 S51 G52 K53 S54 T55 D173 R199 T204 G226 N292 K293 D295 L296 C365 A366 V367 G11 E12 S13 G14 K15 S16 T17 D114 R140 T145 G167 N233 K234 D236 L237 C306 A307 V308
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005525 GTP binding
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:1cjv, PDBe:1cjv, PDBj:1cjv
PDBsum1cjv
PubMed10427002
UniProtP04896|GNAS2_BOVIN Guanine nucleotide-binding protein G(s) subunit alpha isoforms short (Gene Name=GNAS)

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