Structure of PDB 1by4 Chain C

Receptor sequence

>1by4C (length=78) Species: 9606 (Homo sapiens)

KHICAICGDRSSGKHYGVYSCEGCKGFFKRTVRKDLTYTCRDNKDCLIDK
RQRNRCQYCRYQKCLAMGMKREAVQEER

3D structure

• PDB: 1by4 Structural basis of RXR-DNA interactions.
• Chain: C
• Resolution: 2.1 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	dna	C	K2145 H2146 K2156	K14 H15 K25	PDBbind-CN: Kd=350nM
BS02	dna	C	E2153 F2158 R2161 R2184 N2185 Q2188 R2191	E22 F27 R30 R53 N54 Q57 R60	PDBbind-CN: Kd=350nM
BS03	ZN	C	C2135 C2138 C2152 C2155	C4 C7 C21 C24
BS04	ZN	C	C2171 C2177 C2187 C2190	C40 C46 C56 C59

Gene Ontology

Molecular Function

• GO:0003700 DNA-binding transcription factor activity
• GO:0008270 zinc ion binding
• GO:0043565 sequence-specific DNA binding

Biological Process

• GO:0006355 regulation of DNA-templated transcription

External links

• PDB: RCSB:1by4, PDBe:1by4, PDBj:1by4
• PDBsum: 1by4
• PubMed: 10669605
• UniProt: P19793|RXRA_HUMAN Retinoic acid receptor RXR-alpha (Gene Name=RXRA)