Structure of PDB 1bkc Chain C

Receptor sequence
>1bkcC (length=254) Species: 9606 (Homo sapiens) [Search protein sequence]
MKNTCKLLVVADHRFYRYMGRGEESTTTNYLIELIDRVDDIYRNTAWDNA
GFKGYGIQIEQIRILKSPQEVKPGEKHYNMAKSYPNEEKDAWDVKMLLEQ
FSFDIAEEASKVCLAHLFTYQDFDMGTLGLAYVGSPRANSHGGVCPKAYY
SPVGKKNIYLNSGLTSTKNYGKTILTKEADLVTTHELGHNFGAEHDPDGL
AECAPNEDQGGKYVMYPIAVSGDHENNKMFSQCSKQSIYKTIESKAQECF
QERS
3D structure
PDB1bkc Crystal structure of the catalytic domain of human tumor necrosis factor-alpha-converting enzyme.
ChainC
Resolution2.0 Å
3D
structure
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Enzymatic activity
Enzyme Commision number 3.4.24.86: ADAM 17 endopeptidase.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 ZN C H405 H409 H415 H185 H189 H195
BS02 INN C G346 T347 G349 H405 E406 H409 H415 P437 I438 A439 G126 T127 G129 H185 E186 H189 H195 P217 I218 A219
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008237 metallopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1bkc, PDBe:1bkc, PDBj:1bkc
PDBsum1bkc
PubMed9520379
UniProtP78536|ADA17_HUMAN Disintegrin and metalloproteinase domain-containing protein 17 (Gene Name=ADAM17)

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