Structure of PDB 1b12 Chain C

Receptor sequence
>1b12C (length=226) Species: 469008 (Escherichia coli BL21(DE3)) [Search protein sequence]
SFIYEPFQIPSGSMMPTLLIGDFILVEKFATGHPKRGDIVVFKYPEDPKL
DYIKRAVGLPGDKVTYDPVSKELTIQPGCSSGQACENALPVTYSNVEPSD
FVQTFSATSGFFEVPKNETKENGIRLSERKETLGDVTHRILTVPIAQDQV
GMYYQQPGQQLATWIVPPGQYFMMGDNRDNSADSRYWGFVPEANLVGRAT
AIWMSFDKQEGEWPTGLRLSRIGGIH
3D structure
PDB1b12 Crystal structure of a bacterial signal peptidase in complex with a beta-lactam inhibitor.
ChainC
Resolution1.95 Å
3D
structure
Catalytic site residues are labeled in the structure
[Spin on]
[Spin off]
[Reset orientation]

[High quality]
[Low quality]

[White background]
[Black background]

[Download]
[Download structure with residue number starting from 1]
Enzymatic activity
Catalytic site (original residue number in PDB) S88 S90 K145 S278
Catalytic site (residue number reindexed from 1) S11 S13 K54 S181
Enzyme Commision number 3.4.21.89: signal peptidase I.
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 1PN C I86 S88 S90 Y143 I144 K145 S278 A279 I9 S11 S13 Y52 I53 K54 S181 A182
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
Biological Process
GO:0006465 signal peptide processing
GO:0006508 proteolysis
Cellular Component
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:1b12, PDBe:1b12, PDBj:1b12
PDBsum1b12
PubMed9823901
UniProtP00803|LEP_ECOLI Signal peptidase I (Gene Name=lepB)

[Back to BioLiP]