Structure of PDB 1aut Chain C

Receptor sequence
>1autC (length=240) Species: 9606 (Homo sapiens) [Search protein sequence]
LIDGKMTRRGDSPWQVVLLDSKKKLACGAVLIHPSWVLTAAHCMDESKKL
LVRLGEYDLRRWEKWELDLDIKEVFVHPNYSKSTTDNDIALLHLAQPATL
SQTIVPICLPDSGLAERELNQAGQETLVTGWGYHSSREKEAKRNRTFVLN
FIKIPVVPHNECSEVMSNMVSENMLCAGILGDRQDACEGDSGGPMVASFH
GTWFLVGLVSWGEGCGLLHNYGVYTKVSRYLDWIHGHIRD
3D structure
PDB1aut The 2.8 A crystal structure of Gla-domainless activated protein C.
ChainC
Resolution2.8 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB) G193 S195 G196
Catalytic site (residue number reindexed from 1) G189 S191 G192
Enzyme Commision number 3.4.21.69: protein C (activated).
Interaction with ligand
Site
#		 Ligand Ligand
chain		 Binding residues on receptor
(original residue number in PDB)		 Binding residues on receptor
(residue number reindexed from 1)		 Binding affinity
BS01 0G6 C H57 T98 T99 D189 A190 C191 S195 S214 W215 G216 H42 T84 T85 D185 A186 C187 S191 S210 W211 G212
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
Biological Process
GO:0006508 proteolysis

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Molecular Function
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Biological Process
External links
PDB RCSB:1aut, PDBe:1aut, PDBj:1aut
PDBsum1aut
PubMed9003757
UniProtP04070|PROC_HUMAN Vitamin K-dependent protein C (Gene Name=PROC)

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