Structure of PDB 1a4l Chain C
Receptor sequence
>1a4lC (length=349) Species:
10090
(Mus musculus) [
Search protein sequence
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TPAFNKPKVELHVHLDGAIKPETILYFGKKRGIALPADTVEELRNIIGMD
KPLSLPGFLAKFDYYMPVIAGCREAIKRIAYEFVEMKAKEGVVYVEVRYS
PHLLANSKVDPMPWNQTEGDVTPDDVVDLVNQGLQEGEQAFGIKVRSILC
CMRHQPSWSLEVLELCKKYNQKTVVAMDLAGDETIEGSSLFPGHVEAYEG
AVKNGIHRTVHAGEVGSPEVVREAVDILKTERVGHGYHTIEDEALYNRLL
KENMHFEVCPWSSYLTGAWDPKTTHAVVRFKNDKANYSLNTDDPLIFKST
LDTDYQMTKKDMGFTEEEFKRLNINAAKSSFLPEEEKKELLERLYREYQ
3D structure
PDB
1a4l
Complexes of adenosine deaminase with two potent inhibitors: X-ray structures in four independent molecules at pH of maximum activity.
Chain
C
Resolution
2.6 Å
3D
structure
Catalytic site residues are labeled in the structure
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Enzymatic activity
Catalytic site (original residue number in PDB)
H1015 H1017 H1214 E1217 H1238 D1295
Catalytic site (residue number reindexed from 1)
H12 H14 H211 E214 H235 D292
Enzyme Commision number
3.5.4.4
: adenosine deaminase.
Interaction with ligand
Site
#
Ligand
Ligand
chain
Binding residues on receptor
(original residue number in PDB)
Binding residues on receptor
(residue number reindexed from 1)
Binding affinity
BS01
ZN
C
H1015 H1017 H1214 D1295
H12 H14 H211 D292
BS02
DCF
C
H1017 D1019 L1058 F1061 L1062 F1065 M1155 G1184 H1214 E1217 D1295 D1296
H14 D16 L55 F58 L59 F62 M152 G181 H211 E214 D292 D293
Gene Ontology
Molecular Function
GO:0004000
adenosine deaminase activity
GO:0008270
zinc ion binding
GO:0016787
hydrolase activity
GO:0019239
deaminase activity
GO:0046872
metal ion binding
GO:0046936
2'-deoxyadenosine deaminase activity
Biological Process
GO:0000255
allantoin metabolic process
GO:0001666
response to hypoxia
GO:0001701
in utero embryonic development
GO:0001829
trophectodermal cell differentiation
GO:0001889
liver development
GO:0001890
placenta development
GO:0002314
germinal center B cell differentiation
GO:0002467
germinal center formation
GO:0002636
positive regulation of germinal center formation
GO:0002686
negative regulation of leukocyte migration
GO:0002901
mature B cell apoptotic process
GO:0002906
negative regulation of mature B cell apoptotic process
GO:0006154
adenosine catabolic process
GO:0006157
deoxyadenosine catabolic process
GO:0006196
AMP catabolic process
GO:0006915
apoptotic process
GO:0006939
smooth muscle contraction
GO:0007155
cell adhesion
GO:0009117
nucleotide metabolic process
GO:0009168
purine ribonucleoside monophosphate biosynthetic process
GO:0010460
positive regulation of heart rate
GO:0014074
response to purine-containing compound
GO:0019722
calcium-mediated signaling
GO:0030217
T cell differentiation
GO:0030324
lung development
GO:0030890
positive regulation of B cell proliferation
GO:0032261
purine nucleotide salvage
GO:0032263
GMP salvage
GO:0032264
IMP salvage
GO:0033077
T cell differentiation in thymus
GO:0033089
positive regulation of T cell differentiation in thymus
GO:0033632
regulation of cell-cell adhesion mediated by integrin
GO:0042100
B cell proliferation
GO:0042110
T cell activation
GO:0043066
negative regulation of apoptotic process
GO:0043084
penile erection
GO:0043605
amide catabolic process
GO:0044209
AMP salvage
GO:0045580
regulation of T cell differentiation
GO:0045582
positive regulation of T cell differentiation
GO:0045987
positive regulation of smooth muscle contraction
GO:0046059
dAMP catabolic process
GO:0046061
dATP catabolic process
GO:0046085
adenosine metabolic process
GO:0046101
hypoxanthine biosynthetic process
GO:0046103
inosine biosynthetic process
GO:0046111
xanthine biosynthetic process
GO:0046632
alpha-beta T cell differentiation
GO:0046638
positive regulation of alpha-beta T cell differentiation
GO:0048286
lung alveolus development
GO:0048541
Peyer's patch development
GO:0048566
embryonic digestive tract development
GO:0050728
negative regulation of inflammatory response
GO:0050850
positive regulation of calcium-mediated signaling
GO:0050852
T cell receptor signaling pathway
GO:0050862
positive regulation of T cell receptor signaling pathway
GO:0050870
positive regulation of T cell activation
GO:0050900
leukocyte migration
GO:0060169
negative regulation of adenosine receptor signaling pathway
GO:0060407
negative regulation of penile erection
GO:0070242
thymocyte apoptotic process
GO:0070244
negative regulation of thymocyte apoptotic process
GO:0070254
mucus secretion
GO:0070256
negative regulation of mucus secretion
GO:0140928
inhibition of non-skeletal tissue mineralization
Cellular Component
GO:0005737
cytoplasm
GO:0005764
lysosome
GO:0005829
cytosol
GO:0005886
plasma membrane
GO:0009897
external side of plasma membrane
GO:0009986
cell surface
GO:0016020
membrane
GO:0031410
cytoplasmic vesicle
GO:0060205
cytoplasmic vesicle lumen
GO:0070161
anchoring junction
View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB
RCSB:1a4l
,
PDBe:1a4l
,
PDBj:1a4l
PDBsum
1a4l
PubMed
9622483
UniProt
P03958
|ADA_MOUSE Adenosine deaminase (Gene Name=Ada)
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