/var/www/html/BioLiP/script/receptor1 /var/www/html/BioLiP/output/7yl0C.pdb.gz -
ATOM 1 N LYS R 1 75.797 135.711 146.490 1.00186.14 N
ATOM 2 CA LYS R 1 76.852 135.091 145.701 1.00186.14 C
ATOM 3 C LYS R 1 77.097 133.652 146.135 1.00186.14 C
ATOM 4 O LYS R 1 76.466 132.744 145.624 1.00186.14 O
ATOM 5 CB LYS R 1 78.141 135.902 145.793 1.00186.14 C
ATOM 6 CG LYS R 1 78.046 137.266 145.134 1.00186.14 C
ATOM 7 CD LYS R 1 79.403 137.939 145.035 1.00186.14 C
ATOM 8 CE LYS R 1 79.313 139.225 144.232 1.00186.14 C
ATOM 9 NZ LYS R 1 80.627 139.917 144.132 1.00186.14 N
ATOM 10 N CYS R 2 78.014 133.478 147.070 1.00190.10 N
ATOM 11 CA CYS R 2 78.379 132.143 147.492 1.00190.10 C
ATOM 12 C CYS R 2 77.540 131.716 148.729 1.00190.10 C
ATOM 13 O CYS R 2 78.095 131.565 149.816 1.00190.10 O
ATOM 14 CB CYS R 2 79.931 132.129 147.673 1.00190.10 C
ATOM 15 SG CYS R 2 80.916 133.114 146.430 1.00190.10 S
ATOM 16 N ASN R 3 76.213 131.519 148.573 1.00192.23 N
ATOM 17 CA ASN R 3 75.347 131.169 149.673 1.00192.23 C
ATOM 18 C ASN R 3 75.716 129.834 150.252 1.00192.23 C
ATOM 19 O ASN R 3 75.764 129.734 151.449 1.00192.23 O
ATOM 20 CB ASN R 3 73.890 131.125 149.215 1.00192.23 C
ATOM 21 CG ASN R 3 73.322 132.501 148.918 1.00192.23 C
ATOM 22 OD1 ASN R 3 73.805 133.516 149.418 1.00192.23 O
ATOM 23 ND2 ASN R 3 72.285 132.538 148.093 1.00192.23 N
ATOM 24 N THR R 4 76.044 128.832 149.433 1.00191.05 N
ATOM 25 CA THR R 4 76.259 127.475 149.946 1.00191.05 C
ATOM 26 C THR R 4 77.650 127.025 150.410 1.00191.05 C
ATOM 27 O THR R 4 77.817 126.764 151.603 1.00191.05 O
ATOM 28 CB THR R 4 75.732 126.431 148.944 1.00 30.00 C
ATOM 29 OG1 THR R 4 74.322 126.619 148.751 1.00 30.00 O
ATOM 30 CG2 THR R 4 75.985 125.020 149.453 1.00 30.00 C
ATOM 31 N ALA R 5 78.653 126.958 149.530 1.00184.18 N
ATOM 32 CA ALA R 5 79.949 126.424 149.995 1.00184.18 C
ATOM 33 C ALA R 5 81.258 126.753 149.295 1.00184.18 C
ATOM 34 O ALA R 5 81.257 127.059 148.104 1.00184.18 O
ATOM 35 CB ALA R 5 79.845 124.908 150.126 1.00184.18 C
ATOM 36 N THR R 6 82.360 126.742 150.043 1.00176.83 N
ATOM 37 CA THR R 6 83.711 126.871 149.478 1.00176.83 C
ATOM 38 C THR R 6 84.020 127.995 148.484 1.00176.83 C
ATOM 39 O THR R 6 84.590 127.731 147.425 1.00176.83 O
ATOM 40 CB THR R 6 84.165 125.535 148.849 1.00176.83 C
ATOM 41 OG1 THR R 6 83.842 124.454 149.731 1.00176.83 O
ATOM 42 CG2 THR R 6 85.667 125.545 148.596 1.00176.83 C
ATOM 43 N CYS R 7 83.709 129.228 148.821 1.00173.53 N
ATOM 44 CA CYS R 7 83.952 130.276 147.859 1.00173.53 C
ATOM 45 C CYS R 7 85.010 131.239 148.351 1.00173.53 C
ATOM 46 O CYS R 7 84.803 131.950 149.334 1.00173.53 O
ATOM 47 CB CYS R 7 82.662 131.010 147.598 1.00173.53 C
ATOM 48 SG CYS R 7 82.842 132.554 146.701 1.00173.53 S
ATOM 49 N ALA R 8 86.150 131.265 147.671 1.00151.59 N
ATOM 50 CA ALA R 8 87.227 132.121 148.137 1.00151.59 C
ATOM 51 C ALA R 8 87.444 133.275 147.181 1.00151.59 C
ATOM 52 O ALA R 8 87.271 133.108 145.974 1.00151.59 O
ATOM 53 CB ALA R 8 88.499 131.318 148.275 1.00151.59 C
ATOM 54 N THR R 9 87.819 134.434 147.705 1.00140.87 N
ATOM 55 CA THR R 9 88.021 135.614 146.874 1.00140.87 C
ATOM 56 C THR R 9 89.154 136.474 147.348 1.00140.87 C
ATOM 57 O THR R 9 89.171 136.891 148.499 1.00140.87 O
ATOM 58 CB THR R 9 86.780 136.520 146.894 1.00140.87 C
ATOM 59 OG1 THR R 9 85.656 135.797 146.373 1.00140.87 O
ATOM 60 CG2 THR R 9 87.003 137.770 146.057 1.00140.87 C
ATOM 61 N GLN R 10 90.102 136.758 146.473 1.00127.98 N
ATOM 62 CA GLN R 10 91.153 137.687 146.840 1.00127.98 C
ATOM 63 C GLN R 10 90.870 138.924 146.022 1.00127.98 C
ATOM 64 O GLN R 10 90.749 138.852 144.801 1.00127.98 O
ATOM 65 CB GLN R 10 92.533 137.130 146.504 1.00127.98 C
ATOM 66 CG GLN R 10 93.676 138.092 146.770 1.00127.98 C
ATOM 67 CD GLN R 10 95.020 137.398 146.780 1.00127.98 C
ATOM 68 OE1 GLN R 10 95.096 136.175 146.892 1.00127.98 O
ATOM 69 NE2 GLN R 10 96.090 138.174 146.669 1.00127.98 N
ATOM 70 N ARG R 11 90.754 140.064 146.687 1.00126.76 N
ATOM 71 CA ARG R 11 90.439 141.307 146.008 1.00126.76 C
ATOM 72 C ARG R 11 91.639 142.224 146.133 1.00126.76 C
ATOM 73 O ARG R 11 91.996 142.599 147.240 1.00126.76 O
ATOM 74 CB ARG R 11 89.224 141.903 146.701 1.00126.76 C
ATOM 75 CG ARG R 11 88.708 143.221 146.159 1.00126.76 C
ATOM 76 CD ARG R 11 87.503 143.643 146.985 1.00126.76 C
ATOM 77 NE ARG R 11 87.019 144.980 146.655 1.00126.76 N
ATOM 78 CZ ARG R 11 85.989 145.562 147.261 1.00126.76 C
ATOM 79 NH1 ARG R 11 85.340 144.923 148.224 1.00126.76 N
ATOM 80 NH2 ARG R 11 85.607 146.781 146.907 1.00126.76 N
ATOM 81 N LEU R 12 92.300 142.506 145.024 1.00115.44 N
ATOM 82 CA LEU R 12 93.443 143.381 145.104 1.00115.44 C
ATOM 83 C LEU R 12 93.303 144.584 144.197 1.00115.44 C
ATOM 84 O LEU R 12 93.184 144.455 142.978 1.00115.44 O
ATOM 85 CB LEU R 12 94.726 142.616 144.766 1.00115.44 C
ATOM 86 CG LEU R 12 96.048 143.365 144.949 1.00115.44 C
ATOM 87 CD1 LEU R 12 97.228 142.421 144.776 1.00115.44 C
ATOM 88 CD2 LEU R 12 96.150 144.539 143.987 1.00115.44 C
ATOM 89 N ALA R 13 93.321 145.758 144.808 1.00114.35 N
ATOM 90 CA ALA R 13 93.306 147.004 144.052 1.00114.35 C
ATOM 91 C ALA R 13 94.597 147.747 144.340 1.00114.35 C
ATOM 92 O ALA R 13 94.800 148.237 145.456 1.00114.35 O
ATOM 93 CB ALA R 13 92.093 147.859 144.427 1.00114.35 C
ATOM 94 N ASN R 14 95.469 147.813 143.335 1.00113.22 N
ATOM 95 CA ASN R 14 96.749 148.485 143.499 1.00113.22 C
ATOM 96 C ASN R 14 96.845 149.703 142.616 1.00113.22 C
ATOM 97 O ASN R 14 96.634 149.612 141.417 1.00113.22 O
ATOM 98 CB ASN R 14 97.900 147.527 143.213 1.00113.22 C
ATOM 99 CG ASN R 14 99.257 148.127 143.517 1.00113.22 C
ATOM 100 OD1 ASN R 14 100.254 147.772 142.892 1.00113.22 O
ATOM 101 ND2 ASN R 14 99.303 149.039 144.476 1.00113.22 N
ATOM 102 N PHE R 15 97.143 150.845 143.199 1.00111.78 N
ATOM 103 CA PHE R 15 97.287 152.104 142.483 1.00111.78 C
ATOM 104 C PHE R 15 98.618 152.720 142.870 1.00111.78 C
ATOM 105 O PHE R 15 98.892 152.914 144.057 1.00111.78 O
ATOM 106 CB PHE R 15 96.143 153.072 142.810 1.00111.78 C
ATOM 107 CG PHE R 15 94.776 152.450 142.747 1.00111.78 C
ATOM 108 CD1 PHE R 15 94.290 151.697 143.803 1.00111.78 C
ATOM 109 CD2 PHE R 15 93.959 152.647 141.646 1.00111.78 C
ATOM 110 CE1 PHE R 15 93.031 151.132 143.752 1.00111.78 C
ATOM 111 CE2 PHE R 15 92.693 152.085 141.596 1.00111.78 C
ATOM 112 CZ PHE R 15 92.231 151.327 142.649 1.00111.78 C
ATOM 113 N LEU R 16 99.433 153.026 141.867 1.00 96.46 N
ATOM 114 CA LEU R 16 100.748 153.605 142.099 1.00 96.46 C
ATOM 115 C LEU R 16 100.849 154.881 141.280 1.00 96.46 C
ATOM 116 O LEU R 16 100.482 154.886 140.111 1.00 96.46 O
ATOM 117 CB LEU R 16 101.811 152.618 141.631 1.00 96.46 C
ATOM 118 CG LEU R 16 103.247 152.722 142.129 1.00 96.46 C
ATOM 119 CD1 LEU R 16 103.857 151.331 142.077 1.00 96.46 C
ATOM 120 CD2 LEU R 16 104.052 153.679 141.263 1.00 96.46 C
ATOM 121 N VAL R 17 101.335 155.959 141.885 1.00 93.92 N
ATOM 122 CA VAL R 17 101.476 157.226 141.185 1.00 93.92 C
ATOM 123 C VAL R 17 102.868 157.777 141.392 1.00 93.92 C
ATOM 124 O VAL R 17 103.128 158.404 142.399 1.00 93.92 O
ATOM 125 CB VAL R 17 100.502 158.265 141.747 1.00 93.92 C
ATOM 126 CG1 VAL R 17 100.565 159.562 140.951 1.00 93.92 C
ATOM 127 CG2 VAL R 17 99.081 157.730 141.791 1.00 93.92 C
ATOM 128 N HIS R 18 103.770 157.558 140.452 1.00 93.10 N
ATOM 129 CA HIS R 18 105.092 158.124 140.574 1.00 93.10 C
ATOM 130 C HIS R 18 105.085 159.359 139.743 1.00 93.10 C
ATOM 131 O HIS R 18 104.838 159.301 138.555 1.00 93.10 O
ATOM 132 CB HIS R 18 106.139 157.167 140.029 1.00 93.10 C
ATOM 133 CG HIS R 18 107.533 157.713 140.034 1.00 93.10 C
ATOM 134 ND1 HIS R 18 108.477 157.331 140.958 1.00 93.10 N
ATOM 135 CD2 HIS R 18 108.147 158.601 139.213 1.00 93.10 C
ATOM 136 CE1 HIS R 18 109.609 157.961 140.715 1.00 93.10 C
ATOM 137 NE2 HIS R 18 109.437 158.740 139.663 1.00 93.10 N
ATOM 138 N SER R 19 105.361 160.492 140.345 1.00 95.21 N
ATOM 139 CA SER R 19 105.415 161.719 139.597 1.00 95.21 C
ATOM 140 C SER R 19 106.640 162.484 139.964 1.00 95.21 C
ATOM 141 O SER R 19 106.896 162.703 141.132 1.00 95.21 O
ATOM 142 CB SER R 19 104.198 162.567 139.893 1.00 95.21 C
ATOM 143 OG SER R 19 104.334 163.851 139.313 1.00 95.21 O
ATOM 144 N SER R 20 107.415 162.898 138.979 1.00 97.57 N
ATOM 145 CA SER R 20 108.549 163.731 139.288 1.00 97.57 C
ATOM 146 C SER R 20 108.402 164.993 138.506 1.00 97.57 C
ATOM 147 O SER R 20 108.375 164.954 137.292 1.00 97.57 O
ATOM 148 CB SER R 20 109.843 163.045 138.889 1.00 97.57 C
ATOM 149 OG SER R 20 110.925 163.956 138.927 1.00 97.57 O
ATOM 150 N ASN R 21 108.281 166.134 139.162 1.00 97.79 N
ATOM 151 CA ASN R 21 108.245 167.398 138.450 1.00 97.79 C
ATOM 152 C ASN R 21 109.539 168.061 138.795 1.00 97.79 C
ATOM 153 O ASN R 21 109.704 168.524 139.911 1.00 97.79 O
ATOM 154 CB ASN R 21 107.074 168.252 138.898 1.00 97.79 C
ATOM 155 CG ASN R 21 105.736 167.605 138.615 1.00 97.79 C
ATOM 156 OD1 ASN R 21 104.735 167.938 139.246 1.00 97.79 O
ATOM 157 ND2 ASN R 21 105.707 166.679 137.666 1.00 97.79 N
ATOM 158 N ASN R 22 110.476 168.076 137.870 1.00 96.40 N
ATOM 159 CA ASN R 22 111.784 168.626 138.154 1.00 96.40 C
ATOM 160 C ASN R 22 111.913 170.014 137.584 1.00 96.40 C
ATOM 161 O ASN R 22 112.289 170.172 136.433 1.00 96.40 O
ATOM 162 CB ASN R 22 112.836 167.693 137.575 1.00 96.40 C
ATOM 163 CG ASN R 22 114.207 168.312 137.495 1.00 96.40 C
ATOM 164 OD1 ASN R 22 114.910 168.137 136.510 1.00 96.40 O
ATOM 165 ND2 ASN R 22 114.582 169.051 138.508 1.00 96.40 N
ATOM 166 N PHE R 23 111.580 171.040 138.354 1.00100.58 N
ATOM 167 CA PHE R 23 111.811 172.375 137.822 1.00100.58 C
ATOM 168 C PHE R 23 113.211 172.792 138.178 1.00100.58 C
ATOM 169 O PHE R 23 113.384 173.803 138.842 1.00100.58 O
ATOM 170 CB PHE R 23 110.880 173.397 138.464 1.00100.58 C
ATOM 171 CG PHE R 23 109.426 173.181 138.188 1.00100.58 C
ATOM 172 CD1 PHE R 23 108.720 172.185 138.838 1.00100.58 C
ATOM 173 CD2 PHE R 23 108.751 174.012 137.321 1.00100.58 C
ATOM 174 CE1 PHE R 23 107.377 171.996 138.594 1.00100.58 C
ATOM 175 CE2 PHE R 23 107.404 173.836 137.076 1.00100.58 C
ATOM 176 CZ PHE R 23 106.716 172.824 137.711 1.00100.58 C
ATOM 177 N GLY R 24 114.221 172.065 137.740 1.00101.55 N
ATOM 178 CA GLY R 24 115.565 172.386 138.172 1.00101.55 C
ATOM 179 C GLY R 24 116.571 171.381 137.685 1.00101.55 C
ATOM 180 O GLY R 24 116.296 170.636 136.758 1.00101.55 O
ATOM 181 N ALA R 25 117.732 171.330 138.317 1.00 99.93 N
ATOM 182 CA ALA R 25 118.781 170.444 137.840 1.00 99.93 C
ATOM 183 C ALA R 25 118.950 169.191 138.653 1.00 99.93 C
ATOM 184 O ALA R 25 119.142 169.254 139.851 1.00 99.93 O
ATOM 185 CB ALA R 25 120.092 171.193 137.788 1.00 99.93 C
ATOM 186 N ILE R 26 118.880 168.038 137.999 1.00 94.15 N
ATOM 187 CA ILE R 26 119.115 166.768 138.663 1.00 94.15 C
ATOM 188 C ILE R 26 120.323 166.223 137.959 1.00 94.15 C
ATOM 189 O ILE R 26 120.349 166.184 136.744 1.00 94.15 O
ATOM 190 CB ILE R 26 117.998 165.753 138.401 1.00 94.15 C
ATOM 191 CG1 ILE R 26 116.655 166.252 138.906 1.00 94.15 C
ATOM 192 CG2 ILE R 26 118.321 164.407 139.033 1.00 94.15 C
ATOM 193 CD1 ILE R 26 115.574 165.201 138.828 1.00 94.15 C
ATOM 194 N LEU R 27 121.336 165.808 138.690 1.00 96.67 N
ATOM 195 CA LEU R 27 122.480 165.197 138.060 1.00 96.67 C
ATOM 196 C LEU R 27 122.661 163.859 138.712 1.00 96.67 C
ATOM 197 O LEU R 27 122.631 163.757 139.926 1.00 96.67 O
ATOM 198 CB LEU R 27 123.712 166.068 138.266 1.00 96.67 C
ATOM 199 CG LEU R 27 125.058 165.746 137.611 1.00 96.67 C
ATOM 200 CD1 LEU R 27 125.856 167.028 137.431 1.00 96.67 C
ATOM 201 CD2 LEU R 27 125.874 164.719 138.381 1.00 96.67 C
ATOM 202 N SER R 28 122.888 162.826 137.919 1.00 94.85 N
ATOM 203 CA SER R 28 123.050 161.495 138.464 1.00 94.85 C
ATOM 204 C SER R 28 124.095 160.694 137.744 1.00 94.85 C
ATOM 205 O SER R 28 124.170 160.730 136.531 1.00 94.85 O
ATOM 206 CB SER R 28 121.735 160.741 138.404 1.00 94.85 C
ATOM 207 OG SER R 28 121.925 159.383 138.746 1.00 94.85 O
ATOM 208 N SER R 29 124.905 159.951 138.478 1.00 93.36 N
ATOM 209 CA SER R 29 125.901 159.106 137.850 1.00 93.36 C
ATOM 210 C SER R 29 125.877 157.739 138.471 1.00 93.36 C
ATOM 211 O SER R 29 125.989 157.615 139.674 1.00 93.36 O
ATOM 212 CB SER R 29 127.287 159.702 138.013 1.00 93.36 C
ATOM 213 OG SER R 29 128.277 158.782 137.593 1.00 93.36 O
ATOM 214 N THR R 30 125.740 156.702 137.661 1.00 87.13 N
ATOM 215 CA THR R 30 125.792 155.360 138.200 1.00 87.13 C
ATOM 216 C THR R 30 126.964 154.684 137.547 1.00 87.13 C
ATOM 217 O THR R 30 126.970 154.516 136.344 1.00 87.13 O
ATOM 218 CB THR R 30 124.518 154.586 137.867 1.00 87.13 C
ATOM 219 OG1 THR R 30 123.377 155.369 138.234 1.00 87.13 O
ATOM 220 CG2 THR R 30 124.483 153.267 138.613 1.00 87.13 C
ATOM 221 N ASN R 31 127.980 154.313 138.306 1.00 82.15 N
ATOM 222 CA ASN R 31 129.154 153.713 137.717 1.00 82.15 C
ATOM 223 C ASN R 31 129.324 152.316 138.259 1.00 82.15 C
ATOM 224 O ASN R 31 130.067 152.110 139.199 1.00 82.15 O
ATOM 225 CB ASN R 31 130.413 154.512 138.023 1.00 82.15 C
ATOM 226 CG ASN R 31 130.393 155.908 137.441 1.00 82.15 C
ATOM 227 OD1 ASN R 31 131.184 156.758 137.842 1.00 82.15 O
ATOM 228 ND2 ASN R 31 129.502 156.155 136.494 1.00 82.15 N
ATOM 229 N VAL R 32 128.658 151.342 137.660 1.00 77.91 N
ATOM 230 CA VAL R 32 128.736 149.994 138.186 1.00 77.91 C
ATOM 231 C VAL R 32 129.798 149.173 137.489 1.00 77.91 C
ATOM 232 O VAL R 32 129.689 148.893 136.313 1.00 77.91 O
ATOM 233 CB VAL R 32 127.442 149.248 137.939 1.00 77.91 C
ATOM 234 CG1 VAL R 32 127.621 147.791 138.320 1.00 77.91 C
ATOM 235 CG2 VAL R 32 126.297 149.906 138.687 1.00 77.91 C
ATOM 236 N GLY R 33 130.823 148.760 138.228 1.00 75.92 N
ATOM 237 CA GLY R 33 131.875 147.940 137.650 1.00 75.92 C
ATOM 238 C GLY R 33 132.850 148.758 136.838 1.00 75.92 C
ATOM 239 O GLY R 33 133.829 148.227 136.314 1.00 75.92 O
ATOM 240 N SER R 34 132.591 150.055 136.725 1.00 76.59 N
ATOM 241 CA SER R 34 133.466 150.919 135.987 1.00 76.59 C
ATOM 242 C SER R 34 134.715 151.158 136.750 1.00 76.59 C
ATOM 243 O SER R 34 134.740 150.948 137.913 1.00 76.59 O
ATOM 244 CB SER R 34 132.771 152.238 135.748 1.00 76.59 C
ATOM 245 OG SER R 34 133.640 153.160 135.121 1.00 76.59 O
ATOM 246 N ASN R 35 135.791 151.543 136.109 1.00 79.18 N
ATOM 247 CA ASN R 35 136.974 151.894 136.853 1.00 79.18 C
ATOM 248 C ASN R 35 137.610 153.058 136.173 1.00 79.18 C
ATOM 249 O ASN R 35 137.467 153.213 134.988 1.00 79.18 O
ATOM 250 CB ASN R 35 137.952 150.736 136.903 1.00 79.18 C
ATOM 251 CG ASN R 35 137.364 149.498 137.533 1.00 79.18 C
ATOM 252 OD1 ASN R 35 137.110 148.502 136.869 1.00 79.18 O
ATOM 253 ND2 ASN R 35 137.121 149.563 138.820 1.00 79.18 N
ATOM 254 N THR R 36 138.311 153.896 136.901 1.00 87.70 N
ATOM 255 CA THR R 36 139.023 154.979 136.271 1.00 87.70 C
ATOM 256 C THR R 36 140.470 154.830 136.622 1.00 87.70 C
ATOM 257 O THR R 36 140.806 154.717 137.786 1.00 87.70 O
ATOM 258 CB THR R 36 138.530 156.330 136.772 1.00 87.70 C
ATOM 259 OG1 THR R 36 137.107 156.397 136.636 1.00 87.70 O
ATOM 260 CG2 THR R 36 139.162 157.458 135.984 1.00 87.70 C
ATOM 261 N TYR R 37 141.507 154.607 136.044 1.00 20.00 N
ATOM 262 CA TYR R 37 142.974 154.530 136.053 1.00 20.00 C
ATOM 263 C TYR R 37 143.549 155.881 135.707 1.00 20.00 C
ATOM 264 O TYR R 37 142.937 156.632 134.979 1.00 20.00 O
ATOM 265 CB TYR R 37 143.437 153.499 135.025 1.00 20.00 C
ATOM 266 CG TYR R 37 142.990 152.127 135.453 1.00 20.00 C
ATOM 267 CD1 TYR R 37 141.685 151.725 135.231 1.00 20.00 C
ATOM 268 CD2 TYR R 37 143.884 151.266 136.063 1.00 20.00 C
ATOM 269 CE1 TYR R 37 141.273 150.466 135.624 1.00 20.00 C
ATOM 270 CE2 TYR R 37 143.476 150.010 136.460 1.00 20.00 C
ATOM 271 OH TYR R 37 141.764 148.365 136.628 1.00 20.00 O
ATOM 272 CZ TYR R 37 142.168 149.605 136.239 1.00 20.00 C
ATOM 273 NXT TYR R 37 144.745 156.251 136.207 1.00 20.00 N
TER