Structure of PDB 7o80 Chain Bz

Receptor sequence

>7o80Bz (length=595) Species: 9986 (Oryctolagus cuniculus)

KLTRIAIVNHDKCKPKKCRQECKKSCPVVRMGKLCIEVTPQSKIAWISET
LCIGCGICIKKCPFGALSIVNLPSNLEKETTHRYCANAFKLHRLPIPRPG
EVLGLVGTNGIGKSTALKILAGKQKPNLGKYDDPPDWQEILTYFRGSELQ
NYFTKILEDDLKAIIKPQYVDQIPKAAKGTVGSILDRKDETKTQAIVCQQ
LDLTHLKERNVEDLSGGELQRFACAVVCIQKADIFMFDEPSSYLDVKQRL
KAAITIRSLINPDRYIIVVEHDLSVLDYLSDFICCLYGVPSAYGVVTMPF
SVREGINIFLDGYVPTENLRFRDASLVFKVAETANEEEVKKMCMYKYPGM
KKKMGEFELAIVAGEFTDSEIMVMLGENGTGKTTFIRMLAGRLKPDEGGE
VPVLNVSYKPQKISPKSTGSVRQLLHEKIRDAYTHPQFVTDVMKPLQIEN
IIDQEVQTLSGGELQRVALALCLGKPADVYLIDEPSAYLDSEQRLMAARV
VKRFILHAKKTAFVVEHDFIMATYLADRVIVFDGVPSKNTVANSPQTLLA
GMNKFLSQLEITFRRDPNNYRPRINKLNSIKDVEQKKSGNYFFLD

3D structure

• PDB: 7o80 Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.
• Chain: Bz
• Resolution: 2.9 Å

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Bz	R148 G149 S150 E151 Q153 N154 R306 R567 R576 N578 K579 S582 I583 K584	R145 G146 S147 E148 Q150 N151 R303 R564 R573 N575 K576 S579 I580 K581
BS02	rna	Bz	T443 R506	T440 R503
BS03	SF4	Bz	C29 P30 C55 I56 G57 C58 G59 C61	C26 P27 C52 I53 G54 C55 G56 C58
BS04	SF4	Bz	C16 C21 C25 C65 L70	C13 C18 C22 C62 L67

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0005524 ATP binding
• GO:0016887 ATP hydrolysis activity
• GO:0043024 ribosomal small subunit binding

Biological Process

• GO:0000054 ribosomal subunit export from nucleus
• GO:0006413 translational initiation
• GO:0006415 translational termination

External links

• PDB: RCSB:7o80, PDBe:7o80, PDBj:7o80
• PDBsum: 7o80
• PubMed: 34029205
• UniProt: G1SG72