BioLiP

Structure of PDB 7o81 Chain Bv

Receptor sequence

>7o81Bv (length=212) Species: 9986 (Oryctolagus cuniculus) [Search protein sequence]

SRDTLYEAVREVLHGNQRKRRKFLETVELQISLKNYDPQKDKRFSGTVRL
KSTPRPKFSVCVLGDQQHCDEAKAVDIPHMDIEALKKLNKNKKLVKKLAK
KYDAFLASESLIKQIPRILGPGLNKAGKFPSLLTHNENMVAKVDEVKSTI
KFQMKKVLCLAVAVGHVKMTDDELVYNIHLAVNFLVSLLKKNWQNVRALY
IKSTMGKPQRLY

3D structure

PDB

7o81 Structural basis of ribosomal frameshifting during translation of the SARS-CoV-2 RNA genome.

Chain

Resolution

3.1 Å

3D
structure

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Enzymatic activity

Enzyme Commision number

Interaction with ligand

Site #	Ligand	Ligand chain	Binding residues on receptor (original residue number in PDB)	Binding residues on receptor (residue number reindexed from 1)	Binding affinity
BS01	rna	Bv	Q44 R48	Q39 R43
BS02	rna	Bv	R25 R26 K27 F28 T31 E33 Q35 I36 S37 K98 K102 K105 K106 L163 C164 A166 Q199 R202 Y205 K207 M210 P213	R20 R21 K22 F23 T26 E28 Q30 I31 S32 K93 K97 K100 K101 L158 C159 A161 Q194 R197 Y200 K202 M205 P208

Gene Ontology

	Molecular Function
GO:0003723	RNA binding
GO:0003735	structural constituent of ribosome

	Biological Process
GO:0000470	maturation of LSU-rRNA
GO:0006412	translation

	Cellular Component
GO:0005737	cytoplasm
GO:0005840	ribosome
GO:0015934	large ribosomal subunit
GO:0022625	cytosolic large ribosomal subunit
GO:1990904	ribonucleoprotein complex

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Molecular Function

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Biological Process

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Cellular Component

PDB	RCSB:7o81, PDBe:7o81, PDBj:7o81
PDBsum	7o81
PubMed	34029205
UniProt	G1SKZ8\|RL10A_RABIT Large ribosomal subunit protein uL1 (Gene Name=RPL10A)